ArticleOrganic letters2026
Total Synthesis of Voratin C: Formation of the [6,5]-Spiroketal Core through Acid-Mediated Epoxide Cascade Opening.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
An enantioselective total synthesis of voratin C is reported. Key steps include a ketalization through an epoxide-opening cascade to construct the spiroketal core. An enriched Sharpless dihydroxylation, followed by a stereospecific diol-to-epoxide conversion, furnished the key epoxide intermediate. The carbon skeleton of the natural product was assembled in a cross-olefin metathesis between a vinylpyridine and a C10-C18 alkene fragment. The C3 stereocenter was established via an enantioselective Cu-mediated conjugate reduction of an acrylonitrile.
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