Evidence map›Paper›PMID 42389711›Full record

ArticleFrontiers in ophthalmology2026

The traditional Chinese medicine bloodletting therapy at the Taiyang acupoint (No.EX-HN5) for the treatment of periorbital venous malformation: a case report.

Yanli Zhang, Xiaoyun Cao, Chunhong Chen, Zengfang Yu, Dan Li, Chaoqun Zhang, Man Kang

Abstract readCase Reports
In one paragraph

Article in Frontiers in ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanli ZhangNingbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China.
Xiaoyun CaoNingbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China.
Chunhong ChenNingbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China.
Zengfang YuNingbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China.
Dan LiNingbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China.
Chaoqun ZhangNingbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China.
Man KangNingbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This paper presents a case of periorbital venous malformation treated using appropriate Traditional Chinese Medicine interventions. Case presentation: A 27-year-old Asian Han female presented with prominent swelling of the right periorbital region that appeared when looking downward, accompanied by greenish skin discoloration, which resolved upon elevating the head. Initially, the patient did not seek medical attention, attributing the symptoms to fatigue and insufficient rest. However, the swelling recurred upon awakening, prompting the patient to seek medical evaluation at a hospital. Ocular ultrasound and orbital computed tomography (CT) were subsequently performed, resulting in a diagnosis of periorbital VM. Ocular ultrasound revealed the VM measured 2.0×1.28 cm. Additional ophthalmological findings were as follows: intraocular pressure-OD 14 mmHg, OS 16 mmHg; refraction-OD 0.00/-0.25, OS -1.00/-0.25; visual acuity-OD 1.0, OS 0.8. The patient was subsequently referred to the Departments of Traditional Chinese Medicine (TCM) and Ophthalmology, where management was overseen by a TCM ophthalmologist. The physician recommended bloodletting at the ear tips or Taiyang acupoints as part of the treatment and instructed the patient to adhere to this regimen for monitoring and further management. The patient complied with the physician's instructions, undergoing Taiyang acupoint bloodletting once weekly, with approximately 2 mL of blood removed per session. Six months later, follow-up ocular ultrasound demonstrated a reduction in VM size, although minor changes could be attributable to measurement variability. No evidence of lesion growth was observed, prompting further follow-up evaluations. The patient was instructed to abstain from meridian-based Taiyang acupoint bloodletting for two weeks. Serial ocular ultrasound examinations were performed to assess VM size and peripheral blood flow at multiple time points: pre-bloodletting, immediately post-procedure, and at 1, 2, 5, 7, 24 hours, and 3, 7, 12, and 14 days following the intervention. The results indicated the clinical efficacy of combined Chinese and Western interventions, including Taiyang acupoint meridian stabbing and bloodletting therapy, in managing periorbital VM. Conclusion: Taiyang acupoint meridian bloodletting therapy, when applied to a localized periorbital VM, may exert a therapeutic effect. The therapy temporarily reduces blood flow to the VM, alleviates swelling, improves patient comfort, and mitigates tissue compression associated with the lesion. However, this case report focuses exclusively on a localized periorbital VM during follow-up assessment and is intended solely for clinical reference. Medical guidance should be followed for the targeted and comprehensive management of VM.

Indexed as

bloodletting therapyChinese medicine appropriate technologymeridian stabbingperiorbitalvenous malformation

Identifiers

PMID42389711
PMCPMC13318595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.