SynthesisFrontiers in dementia2026
Leveraging artificial intelligence for analysis of the gut microbiome for dementia diagnosis: a scoping review and discussion.
Synthesis in Frontiers in dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Dementia, a multifactorial disease with progressive cognitive decline, has been linked to imbalances in the gut-brain axis. Emerging artificial intelligence tools have augmented the identification of several gastrointestinal biomarkers for differential dementia detection and severity, but current literature lacks a comprehensive review. Aims: This study aims to better quantify the applications of AI in the exploration of the gut microbiome for diagnosis of specific subtypes of dementia. Methods: Primary articles ( Results: Several studies utilized predictive models including random forests and neural networks to demonstrate alterations in the gut microbiota of Alzheimer's disease, an increasingly prevalent dementia subtype. These individuals have notably reduced levels of butyrate-producing bacteria, such as Conclusion: Distinct gut microbial compositions are associated with dementia. Furthermore, elucidating gut-brain interactions and their neurodegenerative implications can identify targets for earlier, synergistic diagnostics. Systematic review registration: https://osf.io/yw2dc/overview.
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