Evidence map›Paper›PMID 42389593›Full record

ArticleiScience2026

Bile acids mediate liver-bone marrow crosstalk.

Daniele Vitale, Mahmoud Karimi Azardaryany, Ghazal Alipour Talesh, Mahsa Shahidi, Vikki Ho, Suat Dervish, F X Himawan Haryanto Jong, Maito Suoh, Jacob George, Saeed Esmaili

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniele VitaleStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.
Mahmoud Karimi AzardaryanyStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.
Ghazal Alipour TaleshStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.
Mahsa ShahidiStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.
Vikki HoStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.
Suat DervishWestmead Research Hub, Westmead Institute for Medical Research, Westmead, NSW, Australia.
F X Himawan Haryanto JongStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.
Maito SuohStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.
Jacob GeorgeStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.
Saeed EsmailiStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disruption of liver metabolism alters immune responses, with maximal immune activation occurring when metabolic stress increases bone marrow hematopoietic stem cell (HSC) activity. We previously showed that sustained HSC activation enhances liver immune surveillance and reduces tumor burden. In the present study, we show that short-term HSC stimulation alone is insufficient for tumor control. Dietary supplementation with cholesterol and cholic acid, however, synergistically stimulates HSC responses and markedly elevates serum taurocholic acid (T-CA). Pharmacological inhibition of the apical sodium-dependent bile acid transporter (ASBT) restores bile acid homeostasis and lowers circulating T-CA, attenuating HSC activation and liver inflammation. Collectively, these findings reveal a bile acid-mediated liver-bone marrow crosstalk with direct implications for metabolic and neoplastic liver diseases.

Indexed as

cancerimmunologyphysiology

Identifiers

PMID42389593
PMCPMC13320317

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.