ArticleiScience2026
Immune hyperactivity in hemodialysis patients is associated with interferon gamma-induced trained immunity.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
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Abstract
Hemodialysis patients experience persistent inflammation marked by pro-inflammatory monocytes. We hypothesized that the hyper-responsiveness of innate immune cells in these patients is facilitated by trained immunity, a form of innate immune memory. Hemodialysis patients displayed elevated monocyte counts, and isolated peripheral blood mononuclear cells showed significantly heightened cytokine responses after Toll-like receptor stimulation, both indicative of trained immunity. Importantly, plasma interferon gamma (IFN-γ) concentrations positively correlated with cytokine responses. Whole-genome RNA-sequencing revealed enrichment of interferon response pathways, particularly in patients whose monocytes exhibited the most pronounced cytokine production upon restimulation.
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