ArticleTherapeutic advances in infectious disease
Vitamin D receptor
Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
18 authors.
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Abstract
Background: Adequate micronutrient absorption remains key for tuberculosis control. Objective: To evaluate the frequency of vitamin D receptor polymorphisms, Design: Pilot cross-sectional study, PTB ( Methods: We measured total vitamin D (25-OH-vitamin D, 25(OH)D) and cathelicidin (LL-37) levels by enzyme-linked immunosorbent assays and analyzed vitamin D receptor (VDR) polymorphisms by PCR-RFLP. We compared the total 25(OH)D and cathelicidin levels across participant demographics and explored the associations with vitamin D receptor polymorphisms. Results: We observed no significant difference in vitamin D levels between PTB and HC (median (IQR) = 36.6 (27.6-48.7) ng/mL and 32.5 (18-46.3) ng/mL, respectively, Conclusion: The observed associations between VDR polymorphisms, vitamin D levels, and cathelicidin levels highlight the need for further studies to clarify the role of host genetic and sociodemographic factors in pulmonary tuberculosis susceptibility and immune response.
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