ArticleJournal of translational internal medicine2026
Causal relationships between irritable bowel syndrome and brain functional networks: A Mendelian randomization study.
Article in Journal of translational internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Visualization analysis of research hotspots and trends in traditional Chinese medicine external therapies for irritable bowel syndrome.Frontiers in medicine · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: The association between irritable bowel syndrome (IBS) and brain function remains unclear. We conducted Mendelian randomization (MR) analysis to investigate the possible causal relationships between them. Methods: We performed bidirectional MR analysis using genome-wide association study data from IBS and 191 brain resting-state functional magnetic resonance imaging (rsfMRI) traits. Odds ratio (OR) with 95% confidence intervals was used to estimate the causal effects. Enrichment analyses were further conducted on genes corresponding to involved single nucleotide polymorphisms. Results: In forward analysis, IBS potentially increased the connectivity between postcentral/ precentral gyrus and cerebellum (OR = 1.15, Conclusions: Our findings provided suggestive evidence for several causal relationship between IBS and rsfMRI phenotypes, in which, cerebellum, subcortical regions, postcentral and precentral gyrus played important roles. These putative causal relationships warrant further validation in independent, ideally larger-scale datasets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.