Evidence map›Paper›PMID 42389266›Full record

ArticleFrontiers in pharmacology2026

Clinodiside A, an active metabolite in Clinopodii herba, alleviates dextran-sulfate-sodium-induced ulcerative colitis.

Xingxing Yang, Yujia Fan, Qiong Lin, Jinxin Ni, Xinsheng Tan, Jiajun Xu, Min Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xingxing YangSchool of Biological and Food Engineering, Hefei Normal University, Hefei, Anhui, China.
Yujia FanSchool of Biological and Food Engineering, Hefei Normal University, Hefei, Anhui, China.
Qiong LinSchool of Biological and Food Engineering, Hefei Normal University, Hefei, Anhui, China.
Jinxin NiSchool of Biological and Food Engineering, Hefei Normal University, Hefei, Anhui, China.
Xinsheng TanSchool of Biological and Food Engineering, Hefei Normal University, Hefei, Anhui, China.
Jiajun XuSchool of Biological and Food Engineering, Hefei Normal University, Hefei, Anhui, China.
Min SunSchool of Biological and Food Engineering, Hefei Normal University, Hefei, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Clinodiside A is a natural bioactive component of Clinopodii herba, a genuine regional herb from Anhui Province (China) with multiple biological activities. This study aimed to explore the therapeutic potential of Clinodiside A in ulcerative colitis (UC). Methods: Dextran sulfate sodium (DSS) was used to establish UC models both Results: Clinodiside A alleviated DSS-induced UC consequences, including weight loss, increased DAI score, colon shortening, and inflammation. These effects were associated with reduced iron overload, reduced lipid peroxidation, and enhanced intestinal epithelial repair. In HCT116 cells, Clinodiside A ameliorated damage, enhanced motility, and promoted recovery of the intestinal epithelium. Discussion: Our research validates the therapeutic and protective effects of Clinodiside A from Clinopodii herba on UC and expands its application potential.

Indexed as

buddlejasaponin IVbClinodiside AClinopodii herbadextran sulfate sodiumulcerative colitis

Identifiers

PMID42389266
PMCPMC13318706

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.