ArticleClinical kidney journal2026
Pre-transplant and persistent post-transplant hyperparathyroidism and kidney transplant outcomes: a systematic review and meta-analysis.
Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Background: Hyperparathyroidism (HPT) is common in chronic kidney disease and may persist after kidney transplantation, but its prognostic significance remains uncertain because of heterogeneous definitions and variable timing of assessment. Methods: We performed a systematic review and meta-analysis of observational studies in adult kidney transplant recipients (KTRs) in accordance with PRISMA 2020 (PROSPERO CRD420261293712). PubMed/MEDLINE and Embase were searched from inception to 9 February 2026. Exposures included pre- and post-transplant parathyroid hormone (PTH)/Persistent HPT assessed as categorical or continuous variables. Outcomes were all-cause mortality, overall graft failure, and death-censored graft failure. Random-effects models were applied, with Hartung-Knapp sensitivity analyses; risk of bias was assessed using QUIPS. Results: 23 studies were included in the systematic review, and 19 studies (26 266 KTRs) contributed to the meta-analyses (3 pre-transplant studies Conclusions: Post-transplant Persistent HPT is a consistent risk marker for mortality and adverse graft outcomes, whereas the prognostic significance of pre-transplant HPT remains to be clarified. Standardized definitions and prospective studies are needed to clarify causality and treatment effects.
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