Evidence map›Paper›PMID 42389018›Full record

ArticleBioactive materials2026

Metal-phenolic nanocapsules enable a self-amplifying cuproptosis-STING cascade for synergistic cancer immunotherapy.

Jie Yu, Ruyue Zhang, Zeyi Sun, Kanaparedu P C Sekhar, Weikai Sun, Xiaoqing Yang, Zhiliang Gao, Jiwei Cui, Dexin Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jie YuDepartment of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Ruyue ZhangKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, and the School of Biomedical Engineering, Shandong University, Jinan, Shandong, 250100, China.
Zeyi SunDepartment of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Kanaparedu P C SekharKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, and the School of Biomedical Engineering, Shandong University, Jinan, Shandong, 250100, China.
Weikai SunDepartment of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Xiaoqing YangInstitute of Advanced Structure Technology, Beijing Institute of Technology, Beijing, 100081, China.
Zhiliang GaoShandong Key Laboratory of Magnetic Field-free Medicine & Functional Imaging, Research Institute of Magnetic Field-free Medicine & Functional Imaging, National Medicine-Engineering Interdisciplinary Industry-Education Integration Innovation Platform, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Jiwei CuiKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, and the School of Biomedical Engineering, Shandong University, Jinan, Shandong, 250100, China.
Dexin YuDepartment of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunosuppressive tumor microenvironment remains a major obstacle to effective cancer immunotherapy, largely due to insufficient initiation and amplification of antitumor immune responses. Herein, we report a mechanism-driven nanotherapeutic strategy that establishes a self-amplifying cuproptosis-STING cascade to overcome tumor immune resistance. The multifunctional copper/manganese-phenolic nanocapsules (HLCM@Cap) undergo pH-responsive release in the acidic tumor microenvironment, enabling efficient intratumoral copper accumulation and triggering cuproptosis characterized by mitochondrial dysfunction and proteotoxic stress. The resulting release of mitochondrial DNA activates the cGAS-STING pathway, while concurrently released Mn

Indexed as

cGAS-STING pathwayCuproptosisImmunotherapyNanocapsuleTumor microenvironment

Identifiers

PMID42389018
PMCPMC13319721

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.