ArticleIndian journal of anaesthesia2026
Dose-response evaluation of intravenous carbetocin for prevention of postpartum haemorrhage during elective caesarean delivery: A parallel-group randomised controlled trial.
Article in Indian journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Postpartum haemorrhage (PPH) is a major cause of maternal morbidity and mortality. Although 100 μg intravenous carbetocin is commonly administered for uterotonic prophylaxis at caesarean delivery, the optimal dose remains uncertain. The primary objective was to evaluate the dose-response relationship of intravenous carbetocin in achieving adequate uterine tone during elective caesarean delivery. Methods: In this randomised, parallel-group, dose-response trial, 100 parturients scheduled for elective caesarean delivery were assigned into five groups to receive intravenous carbetocin at doses of 100 μg, 80 μg, 60 μg, 40 μg, or 20 μg ( Results: Baseline demographic and obstetric characteristics were comparable among groups. Uterine contraction increased progressively from 75% to 85% at 2 minutes to 90-95% at 5 minutes and 95-100% at 10 minutes, with no significant intergroup differences ( Conclusion: In low-risk, non-obese women undergoing elective caesarean delivery under spinal anaesthesia, intravenous carbetocin doses ranging from 20 μg to 100 μg resulted in similar uterotonic response and blood-loss outcomes, with no statistically significant differences between the different dose groups.
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