ReviewCureus2026
A Narrative Review of Biologic Therapies for Type 2 Inflammation in Severe Asthma and Eosinophilic Chronic Obstructive Pulmonary Disease (COPD): Mechanisms, Efficacy, and Safety.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe asthma affects a minority of patients but accounts for disproportionate morbidity, mortality, and healthcare costs. The development of targeted biologic therapies has revolutionized treatment, offering precision medicine approaches based on underlying inflammatory endotypes. Currently approved biologics target immunoglobulin E (omalizumab), interleukin (IL)-5 or its receptor (mepolizumab, reslizumab, depemokimab, and benralizumab), IL-4 receptor α (dupilumab), and thymic stromal lymphopoietin (tezepelumab). These agents have demonstrated substantial reductions in exacerbation rates, improved lung function, corticosteroid-sparing effects, and enhanced quality of life across diverse patient populations. This review examines the mechanisms of action, clinical efficacy, safety profiles, and optimal patient selection strategies for biologic therapies in severe asthma and eosinophilic COPD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.