Evidence map›Paper›PMID 42388927›Full record

ArticleCureus2026

Association of Body Mass Index With Mortality and Clinical Outcomes in Patients With Nonalcoholic Fatty Liver Disease: A Medical Information Mart for Intensive Care IV (MIMIC-IV) Cohort Study.

Miracle C Chukwuma, Abidemi O Akinrinmade, Dhakshayani G Nath, Grace A Gbigbi-Jackson, Redvers Kadzungwa, Nkechi R Ihezie, Adewale A Kuye, Ifunanya R Ekeocha, Adaeze E Uzozie, Anulika Anyata

Abstract read
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Miracle C ChukwumaInternal Medicine, Albany Medical College, Albany, USA.
Abidemi O AkinrinmadeInternal Medicine, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.
Dhakshayani G NathInternal Medicine, American University of Barbados, Bridgetown, BRB.
Grace A Gbigbi-JacksonFamily Medicine, Medical University of South Carolina (MUSC) Health Florence Medical Center, Florence, USA.
Redvers KadzungwaEpidemiology and Public Health, Boston University School of Public Health, Boston, USA.
Nkechi R IhezieMedicine, Allied Physicians Group, New York, USA.
Adewale A KuyePublic Health, Imperial College London, London, GBR.
Ifunanya R EkeochaInternal Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, NGA.
Adaeze E UzozieGeneral Medicine, University of Nigeria Teaching Hospital, Enugu, NGA.
Anulika AnyataCommunity Medicine, Alex Ekwueme Federal University Ndufu-Alike, Abakaliki, NGA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonalcoholic fatty liver disease is a common condition linked to metabolic disorders and increasing healthcare burden. The relationship between body mass index (BMI) and clinical outcomes in this population remains uncertain, with prior studies reporting mixed findings.

objectiveThis study aimed to evaluate the association between BMI and in-hospital mortality among adults with nonalcoholic fatty liver disease, with BMI analyzed as a binary variable (underweight or normal weight vs overweight or obese).

methodsThis retrospective cohort study used data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) version 3.1 database. Adult patients aged 18 years or older with nonalcoholic fatty liver disease were identified using the International Classification of Diseases (ICD) codes, and only the first hospital admission was included. BMI was calculated from recorded height and weight and categorized as underweight or normal weight versus overweight or obese. Multivariable logistic regression was used to estimate adjusted odds ratios for in-hospital mortality. Due to the low number of mortality events, a parsimonious model was applied to reduce overfitting, including age, sex, race, coronary artery disease, and chronic kidney disease as covariates.

resultsA total of 2,955 patients were included. In-hospital mortality was low, with 15 deaths observed. Overweight or obese BMI was not significantly associated with mortality compared to underweight or normal-weight BMI (adjusted odds ratio: 0.42; 95% CI: 0.14-1.27; p=0.124). Increasing age was associated with higher mortality (adjusted odds ratio: 1.05 per year; 95% CI: 1.01-1.10; p=0.024). No significant associations were observed for sex, race, coronary artery disease, or chronic kidney disease.

conclusionBMI was not associated with in-hospital mortality in patients with nonalcoholic fatty liver disease. Age was associated with increased mortality risk. These findings support the need to consider broader clinical factors beyond BMI in risk assessment.

Indexed as

body mass indexmimic-ivmortalitynonalcoholic fatty liver diseaseobesityretrospective cohort

Identifiers

PMID42388927
PMCPMC13322457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.