Evidence map›Paper›PMID 42388856›Full record

ArticleFrontiers in endocrinology2026

Central precocious puberty as the initial manifestation of multisystem involvement caused by

Yaqin Feng, Li Yang, Qing-Bo Xu, Lan-Fang Cao

Erratum issuedAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Yaqin FengJiangxi Provincial Children's Hospital; JXHC Key Laboratory of Precise Prevention and Treatment for Childhood Diabetes, Nanchang, Jiangxi, China.
Li YangJiangxi Provincial Children's Hospital; JXHC Key Laboratory of Precise Prevention and Treatment for Childhood Diabetes, Nanchang, Jiangxi, China.
Qing-Bo XuJiangxi Provincial Children's Hospital; JXHC Key Laboratory of Precise Prevention and Treatment for Childhood Diabetes, Nanchang, Jiangxi, China.
Lan-Fang CaoJiangxi Provincial Children's Hospital; JXHC Key Laboratory of Precise Prevention and Treatment for Childhood Diabetes, Nanchang, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pathogenic loss-of-function variants in the Case presentation: An 8-year-10-month-old male presented with a 1-2-year history of progressive increase in penile length and girth. Physical examination revealed distinctive craniofacial dysmorphism, classic ichthyotic scaling, pubertal changes consistent with precocious puberty, and normal muscle tone without dystonic features. Biochemical testing confirmed markedly elevated serum total testosterone, a positive gonadotropin-releasing hormone (GnRH) stimulation test consistent with CPP, and bone age advanced by 1.2 years relative to chronological age. Neurocognitive assessment identified mild intellectual disability. Family-based whole-exome sequencing and copy number variation (CNV) analysis identified a Conclusion: Precocious puberty has been reported in eleven patients with

Indexed as

Histone-Lysine N-MethyltransferaseMutationMyeloid-Lymphoid Leukemia ProteinPuberty, PrecociousChildHeterozygoteHumansMaleSteryl-SulfataseHistone-Lysine N-MethyltransferaseKMT2B protein, humanMyeloid-Lymphoid Leukemia ProteinSteryl-SulfataseSTS protein, humancentral precocious pubertyKMT2Bpediatric endocrinologySTSX-linked ichthyosis

Identifiers

PMID42388856
PMCPMC13318659

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.