Evidence map›Paper›PMID 42388805›Full record

ArticlebioRxiv : the preprint server for biology2026

Genetic Impacts on Variability of Body Fat Distribution Uncover Gene-Environment and Gene-Gene Interactions.

Xiaopu Zhang, Roby Joehanes, Jiantao Ma, Oliver Pain, Daniel Levy, Kenneth E Westerman, Jordana T Bell

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaopu ZhangDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Roby JoehanesFramingham Heart Study, Framingham, MA, United States.
Jiantao MaFramingham Heart Study, Framingham, MA, United States.
Oliver PainDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.ORCID 0000-0001-5680-3281
Daniel LevyFramingham Heart Study, Framingham, MA, United States.
Kenneth E WestermanClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.

Funding

FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195Wellcome Trust
6 · The paper itself

Abstract

Body fat distribution is a strong predictor of cardiometabolic disease risk. Gene-environment and gene-gene interactions can affect body fat distribution, resulting in differential phenotypic variance across genotype groups that can be detected through variance quantitative trait loci (vQTLs). Using UK Biobank MRI data in conjunction with genetic data, we explored evidence for vQTLs for body fat distribution phenotypes aiming to uncover potential genetic interactions. We identified three vQTLs for liver fat distribution, including rs738408 (

Identifiers

PMID42388805
PMCPMC13317619

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.