Evidence map›Paper›PMID 42388801›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural and functional insights into the Rcs phosphorelay.

Melesse Nune, Anushya Petchiappan, Istvan Botos, Nadim Majdalani, Sydney H Shapiro, Rodolfo Ghirlando, Chin-Hsien Tai, Amila Abeykoon, Ann Marie Stanley, Bridgette M Beach and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Melesse NuneNational Institutes of General and Medical Sciences, National Institutes of Health (NIH/NIGMS), Bethesda, Maryland, USA.
Anushya PetchiappanCenter for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Istvan BotosLaboratory of Molecular Biology, National Institutes of Diabetes and Digestive Diseases, National Institutes of Health (NIH/NIDDK), Bethesda, Maryland, USA.
Nadim MajdalaniCenter for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Sydney H ShapiroLaboratory of Molecular Biology, National Institutes of Diabetes and Digestive Diseases, National Institutes of Health (NIH/NIDDK), Bethesda, Maryland, USA.
Rodolfo GhirlandoLaboratory of Molecular Biology, National Institutes of Diabetes and Digestive Diseases, National Institutes of Health (NIH/NIDDK), Bethesda, Maryland, USA.
Chin-Hsien TaiCenter for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Amila AbeykoonLaboratory of Molecular Biology, National Institutes of Diabetes and Digestive Diseases, National Institutes of Health (NIH/NIDDK), Bethesda, Maryland, USA.
Ann Marie StanleyLaboratory of Molecular Biology, National Institutes of Diabetes and Digestive Diseases, National Institutes of Health (NIH/NIDDK), Bethesda, Maryland, USA.
Bridgette M BeachLaboratory of Molecular Biology, National Institutes of Diabetes and Digestive Diseases, National Institutes of Health (NIH/NIDDK), Bethesda, Maryland, USA.
Susan GottesmanCenter for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Susan K BuchananLaboratory of Molecular Biology, National Institutes of Diabetes and Digestive Diseases, National Institutes of Health (NIH/NIDDK), Bethesda, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Rcs phosphorelay regulates gene expression in response to cell envelope stress and is critical for the virulence of pathogenic bacteria, including

Indexed as

cell envelope stress responseCryo-EMhistidine kinaseIgaARcsCRcsDRcsFRcs phosphorelaytwo-component systems

Identifiers

PMID42388801
PMCPMC13317618

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.