Evidence map›Paper›PMID 42388793›Full record

ArticlebioRxiv : the preprint server for biology2026

Extracellular vesicles from wild-type Epstein-Barr virus-transformed B-cells export host DNA and EBV EBER1.

Michelle L Pleet, Rose Peterson, Stephanie Chidester, Emily H Stack, Madeleine R Druker, Jubin George, Charlotte V Dagli, Abaigeal Donaldson, Joanna Palade, Elizabeth Hutchins and 14 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Michelle L PleetTranslational Nanobiology Section, Laboratory of Pathology, Center for Cancer Research, NCI/NIH, Bethesda, MD, USA.ORCID 0000-0003-0102-711X
Rose PetersonBioinformatics Section, Information Technology Program, Division of Intramural Research, NINDS/NIH, Bethesda, MD, USA.ORCID 0000-0002-3953-147X
Stephanie ChidesterTranslational Nanobiology Section, Laboratory of Pathology, Center for Cancer Research, NCI/NIH, Bethesda, MD, USA.ORCID 0000-0003-4163-3480
Emily H StackViral Immunology Section, Neuroimmunology Branch, NINDS/NIH, Bethesda, MD, USA.ORCID 0009-0008-0115-7321
Madeleine R DrukerViral Immunology Section, Neuroimmunology Branch, NINDS/NIH, Bethesda, MD, USA.ORCID 0009-0007-2680-8306
Jubin GeorgeTranslational Nanobiology Section, Laboratory of Pathology, Center for Cancer Research, NCI/NIH, Bethesda, MD, USA.ORCID 0000-0002-4525-152X
Charlotte V DagliViral Immunology Section, Neuroimmunology Branch, NINDS/NIH, Bethesda, MD, USA.ORCID 0009-0005-1338-4626
Abaigeal DonaldsonViral Immunology Section, Neuroimmunology Branch, NINDS/NIH, Bethesda, MD, USA.ORCID 0009-0007-3670-9256
Joanna PaladeTranslational Genomics Research Institute, Phoenix, AZ, USA.ORCID 0000-0002-6493-2582
Elizabeth HutchinsTranslational Genomics Research Institute, Phoenix, AZ, USA.ORCID 0000-0003-2543-0798
Chang-Sook HongTranslational Nanobiology Section, Laboratory of Pathology, Center for Cancer Research, NCI/NIH, Bethesda, MD, USA.
Nyater NgouthViral Immunology Section, Neuroimmunology Branch, NINDS/NIH, Bethesda, MD, USA.ORCID 0000-0002-5994-3535
Joan OhayonViral Immunology Section, Neuroimmunology Branch, NINDS/NIH, Bethesda, MD, USA.
Maria Chiara MonacoViral Immunology Section, Neuroimmunology Branch, NINDS/NIH, Bethesda, MD, USA.ORCID 0000-0003-0771-0980
Jason SavageTranslational Nanobiology Section, Laboratory of Pathology, Center for Cancer Research, NCI/NIH, Bethesda, MD, USA.
Tapan K MaityMass Spectrometry Resource, Laboratory of Cell Biology, CCR, NCI/NIH, Bethesda, MD, USA.
Weiming YangMass Spectrometry Resource, Laboratory of Cell Biology, CCR, NCI/NIH, Bethesda, MD, USA.
Lisa M JenkinsMass Spectrometry Resource, Laboratory of Cell Biology, CCR, NCI/NIH, Bethesda, MD, USA.ORCID 0000-0003-1245-1338
Ru-Ching HsiaCancer Research Technology Program, CCR, NCI/NIH, Bethesda, MD, USA.ORCID 0000-0002-8449-089X
Ionita C GhiranDepartment of Anesthesia, Beth Israel Deaconess Medical Center Harvard Medical School Boston, MA, USA.ORCID 0000-0001-6655-3298
Kendall van Keuren-JensenTranslational Genomics Research Institute, Phoenix, AZ, USA.ORCID 0000-0001-8833-6323
Kory JohnsonBioinformatics Section, Information Technology Program, Division of Intramural Research, NINDS/NIH, Bethesda, MD, USA.ORCID 0000-0002-6693-3378
Jennifer C JonesTranslational Nanobiology Section, Laboratory of Pathology, Center for Cancer Research, NCI/NIH, Bethesda, MD, USA.ORCID 0000-0002-9488-7719
Steven JacobsonViral Immunology Section, Neuroimmunology Branch, NINDS/NIH, Bethesda, MD, USA.

Funding

Involvement Of Human Viruses Associated With Chronic Neurologic DiseaseZIANS002817 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI JACOBSON, STEVEN · 2009 to 2025
$26.5M
Development and use of nanoFACS for analysis and sorting of nanoparticlesZIABC011502 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2013 to 2025
$8.6M
Immunologic Mechanisms In Experimental Autoimmune Diseases Of The Nervous SystemZIANS002204 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI JACOBSON, STEVEN · 2009 to 2025
$8.5M
Novel Combinations of Radiation and ImmunotherapyZIABC011503 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2013 to 2025
$5.3M
Translational Nanobiology Approaches to Viral Diseases (HIV, HTLV, SARS-CoV2)ZIABC011942 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2020 to 2025
$909k
Intramural NIH HHS ZIA BC011502Intramural NIH HHS ZIA BC011503Intramural NIH HHS ZIA BC011942Intramural NIH HHS ZIA NS002204Intramural NIH HHS ZIA NS002817
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) infection is nearly ubiquitous and strongly linked to multiple sclerosis (MS), but how EBV-infected B cells communicate with distal tissues remains unclear. We performed an integrated multiomic characterization of small extracellular vesicles (sEVs) released from spontaneous lymphoblastoid cell lines (SLCLs) derived from healthy donors and patients with MS, transformed

Indexed as

EBER1EBVEpstein-Barr virusEVsextracellular vesiclesMSmultiple sclerosis

Identifiers

PMID42388793
PMCPMC13317603

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.