Evidence map›Paper›PMID 42388790›Full record

ArticlebioRxiv : the preprint server for biology2026

Deadenylation and Decapping Factors Cooperatively Stimulate Biochemical Activities of DEAD-Box ATPase Dhh1.

Gabriel A Braun, Rakesh Kumar, Alan G Hinnebusch, John D Gross

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Gabriel A BraunDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California, 94158, United States.ORCID 0000-0002-9105-5757
Rakesh KumarDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892, United States.
Alan G HinnebuschDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892, United States.ORCID 0000-0002-1627-8395
John D GrossDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California, 94158, United States.ORCID 0000-0002-1377-4705

Funding

Molecular Mechanisms that Control mRNA Decapping in Biological CondensatesR01GM148881 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John D Gross · 2023 to 2026
$1.3M
NIGMS NIH HHS R01 GM148881
6 · The paper itself

Abstract

The DEAD-box ATPase Dhh1 (DDX6 in humans) is a general activator of 5'-3' mRNA decay that acts between the deadenylation and decapping steps of the pathway, although the exact mechanism of its action remains unclear. Dhh1 has been shown to interact with the MIF4G domain of the central scaffold protein of the Ccr4-Not deadenylase complex, Not1, as well as the decapping activator Edc3. Although structures have been published of Dhh1 in complex with Not1

Identifiers

PMID42388790
PMCPMC13317613

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.