Evidence map›Paper›PMID 42388730›Full record

ArticleFrontiers in genetics2026

Potential role of the

Haolong Ruan, Haobo Wang, Cheng Zhu, Zhihao Li, Yuebumu ASu, Zihan Ji, Yong Li, Lantao Gu, Can Fu, Honghao Yu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haolong Ruan *Engineering Research Center of Rare Disease Prevention and Control, University of Guangxi, Guilin Medical University, Guilin, China.
Haobo Wang *Engineering Research Center of Rare Disease Prevention and Control, University of Guangxi, Guilin Medical University, Guilin, China.
Cheng ZhuInformation Center of Guilin Medical University, Guilin, China.
Zhihao LiEngineering Research Center of Rare Disease Prevention and Control, University of Guangxi, Guilin Medical University, Guilin, China.
Yuebumu ASuEngineering Research Center of Rare Disease Prevention and Control, University of Guangxi, Guilin Medical University, Guilin, China.
Zihan JiEngineering Research Center of Rare Disease Prevention and Control, University of Guangxi, Guilin Medical University, Guilin, China.
Yong LiEngineering Research Center of Rare Disease Prevention and Control, University of Guangxi, Guilin Medical University, Guilin, China.
Lantao GuEngineering Research Center of Rare Disease Prevention and Control, University of Guangxi, Guilin Medical University, Guilin, China.
Can FuEngineering Research Center of Rare Disease Prevention and Control, University of Guangxi, Guilin Medical University, Guilin, China.
Honghao YuEngineering Research Center of Rare Disease Prevention and Control, University of Guangxi, Guilin Medical University, Guilin, China.
Pengpeng YueEngineering Research Center of Rare Disease Prevention and Control, University of Guangxi, Guilin Medical University, Guilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: TRPV4 is a non-selective cation channel of the TRPV family and plays a key role in fibrosis, but its pathological mechanisms in genetically susceptible individuals remain unclear. This study aimed to investigate the potential role of the Methods: The mutation was identified in a family with autosomal dominant familial digital arthropathy-brachydactyly (FDAB). A corresponding gene-edited mouse model was generated using CRISPR/Cas9 technology. Histopathological analysis, single-cell RNA sequencing (scRNA-seq), qPCR, Western blot, and immunofluorescence co-staining were employed to assess phenotypic, transcriptomic, and molecular changes in the lungs. Results: The model mice exhibited skeletal abnormalities and multi-organ damage, with pronounced pulmonary fibrosis. In the lung tissues of homozygous mutant ( Conclusion: The

Indexed as

gene editinglung fibrosismousesingle cell transcriptomicsTRPV4

Identifiers

PMID42388730
PMCPMC13322678

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.