ArticleFrontiers in neurology
CT - derived fractional flow reserve can predict recurrent ischemia in patients with MCA stenosis.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rationale and objectives: CT-derived fractional flow reserve (CT-FFR) has rarely been used to evaluate the hemodynamic changes of cerebral arterial stenosis. We aimed to investigate the role of CT-FFR in predicting recurrent ischemic risk in patients with symptomatic middle cerebral artery (MCA) stenosis. Materials and methods: 124 eligible patients with unilateral MCA stenosis undergoing four-dimensional CTA were retrospectively included. Computational fluid dynamics model was reconstructed from the peak arterial phase CTA to calculate CT-FFR. MTT > 6.5 s was defined as cerebral hypoperfusion. Recurrent ischemic event within 1 year was recorded. Results: Of 124 patients, 19 had recurrent ischemic event, with lower CT-FFR value than non-recurrent ischemia group (median 0.72 vs. 0.83, Conclusion: A CT-FFR threshold specific to CTP-based hypoperfusion may achieve improved value compared to DS alone for predicting recurrent ischemic event within 1 year in patients with symptomatic MCA stenosis.
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