Evidence map›Paper›PMID 42388659›Full record

ArticleJBMR plus2026

Quantitative traits of early-stage osteochondrosis lesions in porcine distal femurs are consistent with skeletal developmental age.

Brittney P Kokinos, Pamela J Lang, Laura A Amundson, Matthew A Halanski, Thomas D Crenshaw

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Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Brittney P KokinosDepartment of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, United States.
Pamela J LangDepartment of Orthopedics and Rehabilitation, Shriners Children's Twin Cities, Woodbury, MN 55125, United States.
Laura A AmundsonDepartment of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, United States.
Matthew A HalanskiDepartment of Child Health, University of Arizona College of Medicine-Phoenix, Phoenix Children's Hospital United States, Pheonix, AZ 85016, United States.
Thomas D CrenshawDepartment of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, United States.ORCID https://orcid.org/0000-0001-8886-0264

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early-stage osteochondrosis (OC) lesions are focal failures of endochondral ossification in the physeal and epiphyseal regions. Lesions are initially detected and quantified as ossification variants using non-invasive imaging methods. The etiology of OC lesions is not understood, as early-stage lesions are rarely imaged in children or animals until symptoms advance to stages that require intervention. The distal femur, a common site for OC lesions, provides an easily accessible, anatomical location to study early-stage development. Non-invasive CT and MRI techniques for distinguishing early-stage lesions were compared in images collected from Cross-sectional and Longitudinal Studies. Osteochondrosis lesion traits in the physeal and epiphyseal regions of swine distal femurs were quantified. Cross-sectional subjects were randomly selected from asymptomatic, crossbred swine at 7, 12, and 24 wk of age. A longitudinal cohort was repeatedly imaged at 6, 12, and 18 wk of age. Subsets of femurs from each age group were selected for histological analysis. Ossification variants defined as abnormal physeal widths without defined OC lesions, were observed at 7 wk. At 12 wk, 2.7 ± 1.8 physeal lesions per pig with an average volume = 9.8 ± 10.0 mm

Indexed as

clinical imagingdevelopmental ageendochondral ossificationossification variantsprimary and secondary center of ossification

Identifiers

PMID42388659
PMCPMC13318846

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.