Evidence map›Paper›PMID 42388611›Full record

ArticleFrontiers in oncology2026

Case Report: Spontaneous regression of cystic renal cell carcinoma.

Zuhuan Xu, Yunfeng Zhang, Penglin Zhang, Honglin Hu

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zuhuan XuDepartment of Urology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yunfeng ZhangDepartment of Urology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Penglin ZhangDepartment of Urology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Honglin HuDepartment of Urology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Spontaneous regression (SR) of cystic renal cell carcinoma (CRCC) is extremely rare, and previous reports lack pathological confirmation. In this review, we report a case of spontaneous partial regression of Bosniak grade IV CRCC confirmed by postoperative pathology, and discuss its potential mechanism. Case summary: A 59-year-old female patient with a simple cyst (34*31 mm) in her left kidney was detected by color doppler flow imaging(CDFI) in July 2023. In October 2024, the computed tomography(CT) showed that the lesion had progressed to Bosniak grade IV cystic mass (60*50 mm), which was not treated. Follow-up magnetic resonance imaging (MRI) in April 2025 showed that the lesion was significantly reduced (25*28 mm). The patient underwent robot-assisted laparoscopic partial nephrectomy, and was pathologically diagnosed with clear cell renal cell carcinoma(ccRCC) after surgery. Conclusions: Despite spontaneous regression, Bosniak grade IV renal cystic disease requires surgical intervention to confirm the diagnosis and avoid progression. This study provides a new basis for the natural history of high-risk renal cystic lesions and individualized follow-up strategies.

Indexed as

Bosniak gradecase reportclear cell renal cell carcinomacystic renal cell carcinomaspontaneous regressiontumor microenvironment

Identifiers

PMID42388611
PMCPMC13318590

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