ArticleCancer diagnosis & prognosis
Total Bone Uptake as a Quantitative Imaging Biomarker for Prostate Cancer With Bone Metastases.
Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background/Aim: Bone scintigraphy is widely used for evaluating bone metastases in prostate cancer, but conventional planar imaging is limited by its qualitative nature and poor reproducibility for longitudinal assessment. The Bone Scan Index (BSI) provides a semiquantitative measure of skeletal tumor burden, but it does not reflect tracer uptake intensity. Quantitative single-photon emission computed tomography/computed tomography (SPECT/CT) allows volumetric assessment of uptake, and total bone uptake (TBU) derived from GI-BONE (Nihon Medi-Physics Co., Ltd, Tokyo, Japan) may offer a more comprehensive biomarker of skeletal disease activity. Patients and Methods: We retrospectively reviewed three patients with prostate cancer and bone metastases who underwent serial Results: In all three cases, serial TBU measurements provided an objective representation of skeletal disease activity over time. Changes in TBU were consistent with the clinical course and treatment response, suggesting that this parameter may be useful for monitoring disease dynamics during follow-up. Conclusion: GI-BONE-derived TBU may be a practical quantitative biomarker for assessing bone metastatic burden and treatment response in prostate cancer. This case series suggests that TBU can complement conventional bone scintigraphy by providing objective and reproducible longitudinal information.
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