Evidence map›Paper›PMID 42388536›Full record

ArticleMaterials today. Advances2026

Enhanced endosomal escape for nanoparticle-enabled co-delivery of doxorubicin and siRNA to overcome multidrug resistance.

Jin Zhai, Allison Surian, Trystin Cote, Wuxia Zhang, Bao-Toan Dang, Yuan Wang, Qianyu Chen, Kazunori Hoshino, Jinhyung Lee, Yupeng Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jin ZhaiDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Allison SurianDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Trystin CoteDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Wuxia ZhangDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Bao-Toan DangDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Yuan WangDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Qianyu ChenDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Kazunori HoshinoDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Jinhyung LeeDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Yupeng ChenDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.

Funding

Computation-aided Molecular Design of DNA-Inspired Janus Base Biomaterials for Intracellular DeliveryR01GM155969 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI Yupeng Chen · 2024 to 2026
$1.2M
NIGMS NIH HHS R01 GM155969
6 · The paper itself

Abstract

Although co-delivery of small-molecule drugs and siRNAs is a promising platform strategy for combination therapy, current delivery systems fail to achieve efficient endosomal escape, limiting cytosolic siRNA bioavailability and therapeutic efficacy. Conventional lipid nanoparticles (LNPs) can co-encapsulate chemotherapeutics and siRNA, but their poor endosomal escape results in suboptimal siRNA bioavailability. Here, we report a novel type of sphere-like nanoparticle (SNP) platform for co-delivery of siRNA and small-molecule drugs that overcomes these limitations. In this system, doxorubicin (DOX) is intercalated within a Janus base nanotube (JBNt) structure, while siRNA is encapsulated through electrostatic interactions, enabling stable co-packaging. Notably, SNPs exhibit significantly enhanced endosomal escape compared with lipid nanoparticles, leveraging JBNt's endosomal escape, attributable to its distinct proton-sponge-mediated buffer capacity, consequently promoting efficient, coordinated cytosolic delivery of both cargos. In a proof-of-concept study, SNP-mediated co-delivery of Multidrug Resistance 1 gene (MDR1/ABCB1)-targeting siRNA and DOX was associated with effective gene silencing and enhanced apoptosis in cancer cells, tumor spheroids, and murine ovarian tumor xenograft models. Collectively, these findings deliver proof-of-concept evidence for SNPs as a promising co-delivery platform for RNA and chemotherapeutics to overcome chemoresistance and improve anticancer efficacy.

Indexed as

Anticancer therapyCo-deliveryEndosomal escapeMultidrug resistanceNanoparticle

Identifiers

PMID42388536
PMCPMC13322303

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