Evidence map›Paper›PMID 42388523›Full record

Observational studyInternational journal of chronic obstructive pulmonary disease2026

Real-Life Effectiveness of Aclidinium/Formoterol on COPD Control: The REDACT Observational Study.

Konstantinos Kostikas, Stylianos Loukides, Nikolaos Tzanakis, Konstantinos Porpodis, Stavros Tryfon, Konstantinos Katsoulis, Georgios Hillas, Ioanna Gioldasi, Evie Delicha, Athena Gogali and 1 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Konstantinos KostikasRespiratory Medicine Department, University of Ioannina, Ioannina, Greece.ORCID 0000-0003-0774-3942
Stylianos LoukidesSecond Respiratory Medicine Department, General University Hospital 'Attikon', Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0002-4278-9922
Nikolaos TzanakisDepartment of Respiratory Medicine, University Hospital of Heraklion, Medical School, University of Crete, Heraklion, Greece.
Konstantinos PorpodisPulmonary Department, Aristotle University of Thessaloniki, G. Papanikolaou Hospital, Thessaloniki, Greece.
Stavros TryfonPulmonary Department (NHS), George Papanikolaou General Hospital of Thessaloniki, Thessaloniki, Greece.
Konstantinos KatsoulisPulmonary Department, 424 Army General Hospital, Thessaloniki, Greece.
Georgios HillasSecond Respiratory Medicine Department, General University Hospital 'Attikon', Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Ioanna GioldasiPharmabide LTD, Athens, Greece.
Evie DelichaASTAT, Athens, Greece.
Athena GogaliRespiratory Medicine Department, University of Ioannina, Ioannina, Greece.ORCID 0000-0002-4321-9446
Marc MiravitllesPneumology Department Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Campus, Barcelona, Spain.ORCID 0000-0002-9850-9520

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: COPD control evaluates changes in patients' status based on clinical impact and stability. There are limited data on the effectiveness of dual bronchodilation on COPD control. Methods: REDACT was a multicenter, prospective, single-arm, longitudinal real-life observational study that evaluated COPD control in uncontrolled COPD patients after 12 weeks of treatment with aclidinium/formoterol (Duaklir Genuair Results: A total of 1038 patients with uncontrolled COPD, mean age 68.9 years, 69.6% male, were recruited and 1014 (97.7%) completed follow-up. The proportion of patients who achieved COPD control at 12 weeks was 83.7% (95% CI 81.3 to 86.0%). Low baseline FEV Conclusion: After 12 weeks of treatment with aclidinium/formoterol, a significant proportion of uncontrolled COPD patients achieved COPD control, with significant improvements in lung function and health status.

Indexed as

Adrenergic beta-2 Receptor AgonistsBronchodilator AgentsFormoterol FumarateLungMuscarinic AntagonistsPulmonary Disease, Chronic ObstructiveTropanesAdministration, InhalationAgedDrug CombinationsFemaleForced Expiratory VolumeHumansLongitudinal StudiesMaleMiddle Agedaclidinium bromideAdrenergic beta-2 Receptor AgonistsBronchodilator AgentsDrug CombinationsFormoterol FumarateMuscarinic AntagonistsTropanesaclidiniumCOPD controlformoterolLABA/LAMA combinationsRADAR score

Identifiers

PMID42388523
PMCPMC13319687

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.