Evidence map›Paper›PMID 42388472›Full record

ArticleFrontiers in medicine2026

Therapeutic outcomes of cryotherapy plus Graston Technique on pain and activities of daily living in individuals with knee pain.

Vanitha Innocent Rani, Akshaya Saikannan, Manal Ibrahim Alrefaee Asiri, Abhilash Venunathan, Kandasamy Muthugounder, Montaha Mohamed Ibrahim Mohamed, Shobana Gangadharan, Amna Hussian Madani Elfeel, Fatima Adam Gaber Mustafa, Jayaprakash Kanthasamy and 2 more

Abstract read
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Vanitha Innocent RaniDepartment of Community and Mental Health Nursing, King Khalid University, Mahayil, Asir, Saudi Arabia.
Akshaya SaikannanDepartment of Anatomy, Vinayaka Mission's Medical College and Hospital, Vinayaka Mission Research Foundation (DU), Karaikal, India.
Manal Ibrahim Alrefaee AsiriDepartment of Community Health Nursing, Nursing College, King Khalid University, Asir, Saudi Arabia.
Abhilash VenunathanDepartment of Medical Surgical Nursing, Co-operative College of Nursing Payyanur, Kerala University of Health Sciences, Kerala, India.
Kandasamy MuthugounderDepartment of Community and Mental Health Nursing, College of Nursing, Khamis Mushait, King Khalid University, Abha, Saudi Arabia.
Montaha Mohamed Ibrahim MohamedDepartment of Adult and Advanced Nursing Care, King Khalid University, Nursing College, Mahayil, Asir, Saudi Arabia.
Shobana GangadharanCollege of Health Sciences, University of Buraimi, Al-Buraimi Governorate, Oman.
Amna Hussian Madani ElfeelDepartment of Medical and Surgical, Nursing College, King Khalid University, Mahayil, Asir, Saudi Arabia.
Fatima Adam Gaber MustafaDepartment of Maternity and Child Health Nursing, Nursing college, King Khalid University, Mahayil, Asir, Saudi Arabia.
Jayaprakash KanthasamyDepartment of Addiction, GRN, Naufar Center under the Ministry of Public Health, Doha, Qatar.
Francis Moses RajappaSt. Xavier College of Nursing, Kumbakonam, Tamil Nadu, India.
Mahendran KaliyamoorthyViMah's Sports and Orthopedic Physical Therapy Centre, Tamil Nadu, Thanjavur, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: This study evaluated the effectiveness of combining cryotherapy with the Graston Technique in reducing pain and improving activities of daily living (ADL) among individuals with non-traumatic knee pain. Methods: A total of 100 participants aged 31-50 years were recruited from August to October 2024. Participants were randomly assigned to either an experimental group (Graston Technique + cryotherapy) or a control group (Graston Technique alone), with 50 participants in each group. Both groups received one treatment session daily for 10 consecutive sessions over 2 weeks, with each session lasting 30-35 min. The Graston Technique was applied using standardized stainless-steel instruments over the quadriceps, hamstring, and peri-patellar regions. In the experimental group, cryotherapy was applied immediately after treatment using cold packs maintained at 10 °C-12 °C for 10-15 min. Pain intensity was assessed using the Visual Analogue Scale (VAS), while functional performance was evaluated using ADL tasks including walking, stair climbing, cross-leg sitting, and toilet activities. Data were analyzed using paired and independent Results: Both groups demonstrated significant improvements following intervention ( Conclusion: The findings suggest that combining cryotherapy with the Graston Technique is more effective than the Graston Technique alone in improving pain and functional ability among individuals with non-traumatic knee pain. This combined intervention may serve as a practical, non-invasive rehabilitation strategy in physiotherapy settings. Future studies should include larger sample sizes and longer follow-up periods to evaluate long-term clinical outcomes.

Indexed as

ADLcryotherapyGraston Techniqueinstrument-assisted soft tissue mobilizationknee painpain intensityrehabilitation

Identifiers

PMID42388472
PMCPMC13318686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.