ArticleJournal of biomedical optics2026
Multimodal optical imaging for the assessment of the teratogenic effects of ethanol on zebrafish development.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Significance: Prenatal alcohol exposure is a major cause of neurodevelopmental and growth impairments collectively termed fetal alcohol spectrum disorders (FASD). However, the mechanisms by which ethanol disrupts early embryonic development remain incompletely understood; for example, the potential link between ethanol treatment and biomechanical properties of tissues that lead to defects in development is not understood. Aim: To address this gap in knowledge, we used zebrafish ( Approach: Embryos were exposed to varying concentrations of ethanol and assessed using a multimodal imaging approach integrating light sheet fluorescence microscopy, optical coherence tomography, and optical coherence elastography. Results: This platform enabled high-resolution, noninvasive, and parallel visualization of structural, molecular, and biomechanical changes. We found that ethanol exposure disrupts Wnt ligand expression in the nervous system, which correlates with a cascade of morphological abnormalities consistently detected across imaging modalities and consistent with alterations to Conclusions: These findings highlight the critical role of
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