ArticleFrontiers in pediatrics2026
Case Report: Reversible myelodysplastic syndrome secondary to sodium valproate in an epileptic child.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: We report a rare case of sodium valproate (VPA)-induced reversible myelodysplastic syndrome (MDS) in an Asian child with epilepsy, thus expanding the recognition of VPA-associated hematological toxicity. Although VPA has been widely used, the reversibility of MDS as a complication remains underreported, particularly in pediatric populations. Case summary: A 9-year-old boy with epilepsy developed pancytopenia (hemoglobin level: 77 g/L, platelet count: 83 × 10 Conclusion: The reversibility of VPA-induced MDS following dose adjustment underscores the importance of vigilant hematological monitoring in children.
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