Evidence map›Paper›PMID 42388320›Full record

ArticleFrontiers in microbiology2026

Adaptive reprogramming of carbon-nitrogen metabolism in

Yanyan Chen, Meiqi Zhong, Minghan Lu, Jinpeng Huang, Hongrong Liang, Haonan Zou, Lele Xu, Yongqin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanyan ChenSchool of Life Sciences and Technology, Lingnan Normal University, Zhanjiang, Guangdong, China.
Meiqi ZhongSchool of Life Sciences and Technology, Lingnan Normal University, Zhanjiang, Guangdong, China.
Minghan LuSchool of Life Sciences and Technology, Lingnan Normal University, Zhanjiang, Guangdong, China.
Jinpeng HuangSchool of Life Sciences and Technology, Lingnan Normal University, Zhanjiang, Guangdong, China.
Hongrong LiangSchool of Life Sciences and Technology, Lingnan Normal University, Zhanjiang, Guangdong, China.
Haonan ZouSchool of Life Sciences and Technology, Lingnan Normal University, Zhanjiang, Guangdong, China.
Lele XuSchool of Life Sciences and Technology, Lingnan Normal University, Zhanjiang, Guangdong, China.
Yongqin LiSchool of Life Sciences and Technology, Lingnan Normal University, Zhanjiang, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: This study examined its physiological and metabolomic responses to nitrogen‑deficient (DM1) and nitrate‑rich (DM2) conditions using nitrogen balance analysis and metabolomic profiling. Results: Nitrogen balance analysis showed that 83.28% of supplied nitrate in DM2 was incorporated into biomass, with 16.16% released as gaseous nitrogen. Metabolomic profiling revealed upregulation of TCA cycle intermediates (e.g., α‑ketoglutaric acid, succinic acid) and amino acids (e.g., lysine, arginine) under DM2, indicating enhanced carbon flux toward nitrogen assimilation. Downregulation of isocitric acid and acetyl‑CoA suggested rerouting of carbon skeletons to support active nitrogen utilization. KEGG pathway analysis highlighted lysine degradation, glyoxylate metabolism, and taurine pathways in facilitating this metabolic shift. Discussion: These findings demonstrate that

Indexed as

amino acid metabolismaquatic microbiologyKlebsiella aerogenes B23metabolomicsTCA cycle

Identifiers

PMID42388320
PMCPMC13319891

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.