ArticleFrontiers in microbiology2026
Multi-omics analysis of polysaccharide accumulation and associated metabolic reprogramming across developmental stages of
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Polysaccharides are important bioactive components of Methods: Five developmental stages were examined, including primordia (T1), immature fruiting body (T2), pre-basidiospore discharge (T3), basidiospore discharge (T4), and the end of basidiospore discharge (T5). Crude polysaccharide content was determined, and transcriptomic and untargeted metabolomic analyses were integrated to identify key pathways, genes, and metabolites associated with polysaccharide accumulation. Selected genes were further validated by qRT-PCR. Results: Crude polysaccharide content increased from T1 to T3, reached a maximum at T3 (0.90 g/100 g), and subsequently declined. A total of 5,676 differentially expressed genes and 911 differentially accumulated metabolites were identified, with clear stage-dependent separation at both transcriptomic and metabolomic levels. Integrated KEGG analysis indicated that starch and sucrose metabolism was the core pathway associated with polysaccharide accumulation, whereas galactose metabolism functioned as a supplementary module contributing to precursor supply and structural diversification. Dynamic expression of Discussion: These findings indicate that polysaccharide accumulation in
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