ReviewFrontiers in microbiology2026
Circadian rhythms of gut microbiota modulate nocturnal hyperglycemia in type 2 diabetes: a comprehensive review on mechanisms and chrono-targeted interventions.
Review in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Nocturnal hyperglycemia is a critical yet poorly controlled risk factor for complications in type 2 diabetes mellitus (T2DM), highlighting an unmet clinical need. The gut microbiota, a key regulator of host metabolism and circadian rhythms, has emerged as a pivotal player in this process, offering a novel therapeutic target. This article elaborates on the relationship between gut microbiota and nocturnal blood glucose control in T2DM from four key dimensions: the core gut microbiota-circadian clock, regulation by gut microbiota metabolites, the intestinal biological barrier, and neuroendocrine pathway mechanisms. Building on this, the article further explores gut microbiota-based intervention strategies: probiotic/prebiotic supplementation, time-restricted eating (TRE), and photobiomodulation therapy (PBMT). By integrating insights into the gut microbiota and circadian rhythms, this review proposes a novel therapeutic approach for patients with T2DM, offering concrete clinical guidance to improve nocturnal glycemic control.
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