ArticleFrontiers in microbiology2026
Characterization of the gastric mucosal microbiota in tumoral and peritumoral mucosa in patients with advanced gastric cancer from Northwest China.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Herbal Medicine and the Gastrointestinal Microbiota in Gastric Precancerous Lesions and Gastric Cancer: Mechanistic Evidence and Translational Challenges.Cancer management and research · 2026Review
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7 authors.
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Abstract
Introduction: The gastric microbiota affects tumor development and treatment response, yet the characteristics and interactions of mucosal bacteria and fungi in advanced gastric cancer (AGC) remain unclear. Methods: Here we analyzed 177 mucosal samples (88 peritumoral and 89 tumoral) from 91 AGC patients in Northwest China using shotgun metagenomic sequencing. Results: MetaPhlAn4 and Kaiju were used to annotate the gastric mucosal microbial composition. MetaPhlAn4 has identified 12 phyla (no phylum-level differences), 98 genera and 278 species. PERMANOVA revealed age and tumor location significantly influenced microbial composition in tumoral mucosa. Wilcoxon signed-rank test revealed that 10 species including Discussion: This study comprehensively characterizes the gastric mucosal bacteriome and mycobiome in AGC, illuminates potential microbiota-mediated carcinogenic mechanisms, identifies candidate biomarkers, and fills a regional research gap.
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