ArticleOphthalmology science2026
Split-Spectrum Amplitude-Decorrelation Optoretinography Detects Impaired Photoreceptor Function in Age-Related Macular Degeneration.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To assess photoreceptor functional impairment in eyes with early-to-intermediate age-related macular degeneration (AMD) using OCT-based split-spectrum amplitude-decorrelation optoretinography (SSADOR). Design: Prospective observational comparative study. Participants: Adults ≥50 years of age with early or intermediate AMD and age-matched control subjects. Methods: Split-spectrum amplitude-decorrelation optoretinography measures flash-evoked OCT amplitude fluctuations within the photoreceptor outer segment band to objectively quantify photoreceptor light responses. We compared SSADOR mean decorrelation between AMD and control eyes within the central 3-mm macula and across ETDRS subfields and evaluated associations with best-corrected visual acuity (BCVA) and drusen volume. Main Outcome Measures: Split-spectrum amplitude-decorrelation optoretinography mean decorrelation within ETDRS subfields, as a surrogate marker of the light sensing function of photoreceptors. Results: Twenty-two eyes with early-to-intermediate AMD and 12 control eyes were enrolled in the study. Split-spectrum amplitude-decorrelation optoretinography decorrelation was significantly reduced in AMD eyes compared with controls across all ETDRS subfields (all Conclusions: Split-spectrum amplitude-decorrelation optoretinography detected impaired photoreceptor light responses in eyes with early-to-intermediate AMD compared with age-matched controls and outperformed BCVA in differentiating AMD from normal eyes. Split-spectrum amplitude-decorrelation optoretinography decorrelation may serve as a sensitive, objective biomarker for detecting and monitoring early or subtle photoreceptor dysfunction in AMD. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.