ArticleBiochemistry and biophysics reports2026
Effects of metformin and exercise on Alzheimer's model induced by D-galactose in the rats: A behavioral, histological and BDNF gene study.
Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
The objective of the current research is to investigate the cognitive performance of male Alzheimer's disease rats in the context of the combined effects of exercise and metformin. The rats were divided into eight different groups. The Morris water maze (MWM) and the open field test (OFT) were employed to assess the cognitive functionality and motor activity of rats, respectively. The hippocampus of rats was subjected to histological evaluation, and expression of brain-derived neurotrophic factor (BDNF) was measured using the real-time polymerase chain reaction (RT-PCR) method. On concluding day of training, the d-gal-met100-exe group (D-galactose plus optimized 100mg/kg of metformin along with exercise) exhibited a diminished duration in the target quadrant (
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