Evidence map›Paper›PMID 42388206›Full record

ArticleStem cells international2026

In Vitro Evaluation of Mechanical Fat Processing Devices: Impact on Adipocytes and Adipose-Derived Stem Cells.

Sheila Veronese, Riccardo Ossanna, Sara Ghazanfar Tehrani, Lorena Torroni, Patricija Kasilovska, Mario Goisis, Giamaica Conti, Domenico Amuso, Antonio Scarano, Andrea Sbarbati

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In one paragraph

Article in Stem cells international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sheila VeroneseDepartment of Neuroscience, Biomedicine and Movement, Section of Anatomy and Histology, University of Verona, Verona, 37134, Italy, univr.it.ORCID https://orcid.org/0000-0002-6707-3306
Riccardo OssannaDepartment of Neuroscience, Biomedicine and Movement, Section of Anatomy and Histology, University of Verona, Verona, 37134, Italy, univr.it.
Sara Ghazanfar TehraniDepartment of Neuroscience, Biomedicine and Movement, Section of Anatomy and Histology, University of Verona, Verona, 37134, Italy, univr.it.
Lorena TorroniSaint Camillus International University of Health and Medical Sciences, Roma, 00131, Italy.
Patricija KasilovskaLuigi Vanvitelli University, Napoli, Italy.
Mario GoisisDe Clinic, Viale Regina Giovanna 39, Milan, 20129, Italy.
Giamaica ContiDepartment of Neuroscience, Biomedicine and Movement, Section of Anatomy and Histology, University of Verona, Verona, 37134, Italy, univr.it.
Domenico AmusoDepartment of Innovative Technology in Medicine and Dentistry, University of Chieti-Pescara, Via Dei Vestini 31, Chieti, 66100, Italy, unich.it.
Antonio ScaranoDepartment of Innovative Technology in Medicine and Dentistry, University of Chieti-Pescara, Via Dei Vestini 31, Chieti, 66100, Italy, unich.it.ORCID https://orcid.org/0000-0003-1374-6146
Andrea SbarbatiDepartment of Neuroscience, Biomedicine and Movement, Section of Anatomy and Histology, University of Verona, Verona, 37134, Italy, univr.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the fat grafting procedure, the new European Regulations and the necessity to perform minimal manipulation processing require the verification of security and performance levels of each device and, in this particular context, functional and tissue responses. The aim of this study is to evaluate the integrity of adipocytes and adipose-derived stromal/stem cells (ADSCs) after their processing using two new mechanical devices operating with a closed system. In this study, two new fat processing systems were assessed. We also considered the biological results of the processing and compared them with the results obtained from Coleman's procedure, the golden standard procedure in fat processing. Histological evaluations revealed the preservation of the fat morphology after both processing types, with similar cellular yields of the extracted ADSCs. The adopted techniques enable the isolation of ADSCs with robust differentiation potential toward adipogenic, chondrogenic, and osteogenic lineages. Furthermore, adipose tissue samples exhibit high efficiency in extracellular vesicle secretion, indicating a promising potential for therapeutic and regenerative applications. The results suggest that the new systems allow the preservation of fat morphology, stemness, and regenerative potential. The novel processing technique proposed by the authors consists of a closed-loop mechanical system that combines continuous filtration and emulsification of adipose tissue through saline washing, aimed at removing biological debris and residual pharmacological agents.

Indexed as

ADSCfat graftinglipofillingmechanical fat processingmesenchymal stem cellsnonenzymatic fat processing

Identifiers

PMID42388206
PMCPMC13319391

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.