Evidence map›Paper›PMID 42388079›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

Engineering Functional Graphenic Materials for Bone Repair.

Sebastian Guajardo, Jason D Orlando, Chenyun Deng, Anne M Arnold, Stefanie A Sydlik

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Engineering Functional Graphenic Materials for Bone Repair.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sebastian GuajardoDepartment of Chemistry, Carnegie Mellon University, Mellon College of Science, Pittsburgh, Pennsylvania, USA.
Jason D OrlandoDepartment of Chemistry, Carnegie Mellon University, Mellon College of Science, Pittsburgh, Pennsylvania, USA.
Chenyun DengDepartment of Chemistry, Carnegie Mellon University, Mellon College of Science, Pittsburgh, Pennsylvania, USA.
Anne M ArnoldDepartment of Chemistry, Carnegie Mellon University, Mellon College of Science, Pittsburgh, Pennsylvania, USA.
Stefanie A SydlikDepartment of Chemistry, Carnegie Mellon University, Mellon College of Science, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-9375-2356

Funding

National Science Foundation Division of Materials Research 1905665Scott Institute Seed Fund
6 · The paper itself

Abstract

Graphene oxide (GO), a chemically versatile and biocompatible derivative of graphene, has emerged as a highly promising material in the field of bone tissue engineering. This review explores the multifaceted role of GO and other functional graphenic materials (FGMs) in supporting bone regeneration by enhancing osteogenesis, angiogenesis, immunomodulation, and biomineralization. We begin by detailing the physiological principles of bone healing, current clinical approaches to bone repair, and the limitations they present. The discussion then progresses through the chemical foundations of GO and its derivatives, emphasizing their unique surface chemistry and tunable reactivity that enable precise functionalization for biomedical applications. Finally, we highlight the potential of FGM-based composites, with integrated biological molecules, polymers, and small organic compounds, to serve as bioactive, bioresorbable scaffolds that support bone growth and integration. By bridging material science with regenerative medicine, this review underscores the importance of GO as a versatile platform for next-generation bone regeneration strategies.

Indexed as

Biocompatible MaterialsBone RegenerationGraphiteTissue EngineeringAnimalsBone and BonesHumansTissue ScaffoldsBiocompatible Materialsgraphene oxideGraphitebone regenerationcovalent surface functionalizationfunctional graphenic materialsgraphene oxidetissue engineering scaffolds

Identifiers

PMID42388079
PMCPMC13324413

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.