SynthesisEuropean journal of pain (London, England)2026
Utility of Vibration Perception Thresholds as a Biomarker of Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
Synthesis in European journal of pain (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Beyond symptoms: wearable digital biomarkers for subclinical detection of chemotherapy-induced peripheral neuropathy.Frontiers in oncology · 2026Article
- Utidelone-associated chemotherapy-induced peripheral neuropathy: an evidence-stratified narrative review of mechanisms, risk identification, and management strategies.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveChemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and treatment-limiting adverse effect of many agents used for cancer treatment. There is currently no gold-standard diagnostic criterion nor a widely accepted method for accurate and early identification of CIPN. Vibration perception threshold (VPT), which reflects large-fibre nerve function, has been proposed as a potential biomarker for CIPN. DATABASES AND DATA TREATMENT: A systematic review and meta-analysis was pre-registered and conducted by searching PubMed, EMBASE, Scopus, CENTRAL, and Web of Science databases from inception to November 2024. The primary outcome was the change in VPT following neurotoxic chemotherapy compared to the baseline/control group. PROSPERO CRD42024584611.
resultsThirty-one studies involving 1635 participants were included in the final analysis. There was a moderate-to-large increase of VPT following chemotherapy in both the hands (pooled SMD = 0.75, 95% CI [0.52, 0.97]) and feet (SMD = 0.69 95% CI [0.50, 0.88]). Heterogeneity of effects was larger in the hands (I
conclusionsThis study demonstrates consistent increases in VPT (loss of sensitivity) following chemotherapy. Future studies should incorporate clear CIPN diagnostic criteria, comparative analyses between patients with and without CIPN, and longitudinal testing to determine the utility of VPT as an early biomarker of neurotoxicity. SIGNIFICANCE: This review demonstrates that vibration perception threshold (VPT) consistently worsens following chemotherapy, with moderate pooled effect sizes. Comparable changes were observed in both the hands and feet, and combination therapy with taxane and platinum agents was associated with greater deterioration in vibration perception measured in the hand. Together, they support VPT as a promising objective measure that can contribute to the assessment of peripheral neurotoxicity, with hand-based testing potentially offering a practical and sensitive site for assessment.
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