Evidence map›Paper›PMID 42387842›Full record

Observational studyActa paediatrica (Oslo, Norway : 1992)2026

Critically Ill Children Show Disrupted Sleep Patterns and Atypical Electroencephalograms: An Observational Cohort Study.

Eris van Twist, Arnout B G Cramer, Sascha C A T Verbruggen, Maartje Louter, Karlien Veldscholte, Koen F M Joosten, Matthijs de Hoog, Karla Biesheuvel, Dirk C G Straver, Rogier C J de Jonge

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eris van TwistDivision of Paediatric Intensive Care, Department of Neonatal and Paediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0002-0968-5400
Arnout B G CramerDivision of Paediatric Intensive Care, Department of Neonatal and Paediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.
Sascha C A T VerbruggenDivision of Paediatric Intensive Care, Department of Neonatal and Paediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.
Maartje LouterDivision of Clinical Neurophysiology, Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0002-1604-3262
Karlien VeldscholteDivision of Paediatric Intensive Care, Department of Neonatal and Paediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.
Koen F M JoostenDivision of Paediatric Intensive Care, Department of Neonatal and Paediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.
Matthijs de HoogDivision of Paediatric Intensive Care, Department of Neonatal and Paediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.
Karla BiesheuvelDivision of Clinical Neurophysiology, Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
Dirk C G StraverDivision of Clinical Neurophysiology, Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0003-3694-9843
Rogier C J de JongeDivision of Paediatric Intensive Care, Department of Neonatal and Paediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0003-0595-1983

Funding

Erasmus MC Sophia Foundation S19-33
6 · The paper itself

Abstract

aimSleep disruptions are common in hospitalised children. This study described sleep in critically ill and non-critically ill hospitalised children, including young infants and patients with central nervous system injuries.

methodsThis observational cohort study included two groups: critically ill children admitted to a paediatric intensive care unit with expected stay of ≥ 48 h, and non-critically ill children with suspected sleep disordered breathing. Critically ill children were recruited within two clinical studies conducted between 2020 and 2022. Non-critically ill children were recruited from a retrospective database spanning between 2017 and 2021. Sleep was measured using polysomnography and compared with age-specific reference ranges.

resultsWe included 25 critically ill and 120 non-critically ill children. Median ages were 3.6 (1.0-20.4) and 36.7 (6.1-107.7) months, respectively. In critically ill children, nighttime total sleep time accounted for only 50.9% (49.5-55.5) of 24 h sleep. Rapid eye movement (REM) and deep sleep were reduced in 96.0% and 66.7%, respectively. Electroencephalographic (EEG) abnormalities were common (76.0%). Non-critically ill children had reduced REM sleep in early infancy and shorter, fragmented sleep in older children.

conclusionCritically ill children had disrupted sleep and atypical EEG, while non-critically ill children mainly had reduced fragmented sleep.

Indexed as

Critical IllnessElectroencephalographyAdolescentChildChild, PreschoolCohort StudiesFemaleHumansInfantIntensive Care Units, PediatricMalePolysomnographyRetrospective Studiescritically ill childrenelectroencephalographynon‐rapid‐eye movement sleeppaediatric intensive care unitpolysomnographyrapid eye movement sleepsleepsleep disordered breathing

Identifiers

PMID42387842
PMCPMC13552596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.