ArticleJournal of medicinal chemistry2026
Hybrids of Benzenesulfonamide Oxadiazole Derivatives with Dual CA II and COX-2 Inhibitory Activity Demonstrating Antiglaucoma and Anti-inflammatory Action: Synthesis, In Silico Insights, and In Vitro and In Vivo Bioevaluation.
Manal Abdel Fattah Ezzat, Emad M Seif, Husam Nassar, Alessandro Bonardi, Marta Ferraroni, Ahmed A Attia, Yomna T T Khater, Rabab Ahmed Rasheed, Omnia A M Abd El-Ghafar, Heba Abdelrasheed Allam and 4 more
Abstract read
In one paragraphArticle in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Manal Abdel Fattah EzzatDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.ORCID 0000-0002-3924-1536 Emad M SeifDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts University (MSA), Giza 12451, Egypt.ORCID 0000-0003-1505-4004 Husam NassarDepartment of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale) 06120, Germany.
Alessandro BonardiDepartment NEUROFARBA─Pharmaceutical and Nutraceutical Section, University of Firenze, Via Ugo Schiff 6, Sesto Fiorentino I-50019, Firenze, Italy.
Marta FerraroniDepartment of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino I-50019, Italy.ORCID 0000-0001-7258-738X Ahmed A AttiaMansoura Ophthalmic Centre, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Yomna T T KhaterMedical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Rabab Ahmed RasheedDepartment of Medical Histology and Cell Biology, School of Medicine, Badya University, Giza 12573, Egypt.
Omnia A M Abd El-GhafarDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef 62764, Egypt.
Heba Abdelrasheed AllamDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.ORCID 0000-0001-6176-7035 Andrea AngeliNEUROFARBA Department, Sezione di Scienze Farmaceutiche, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino 50019, Florence, Italy.ORCID 0000-0002-1470-7192 Matthias SchmidtDepartment of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale) 06120, Germany.
Claudiu T SupuranDepartment NEUROFARBA─Pharmaceutical and Nutraceutical Section, University of Firenze, Via Ugo Schiff 6, Sesto Fiorentino I-50019, Firenze, Italy.ORCID 0000-0003-4262-0323 Hany S IbrahimDepartment of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale) 06120, Germany.ORCID 0000-0002-1048-4059 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
In this study, new sulfonamide derivatives
Indexed as
Anti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalCarbonic Anhydrase IICarbonic Anhydrase InhibitorsCyclooxygenase 2 InhibitorsGlaucomaOxadiazolesSulfonamidesAnimalsBenzenesulfonamidesCrystallography, X-RayCyclooxygenase 2HumansIntraocular PressureMaleMiceAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalBenzenesulfonamidesCarbonic Anhydrase IICarbonic Anhydrase InhibitorsCyclooxygenase 2Cyclooxygenase 2 InhibitorsOxadiazolesSulfonamides
Identifiers
PMID42387821
PMCPMC13403231
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