Evidence map›Paper›PMID 42387659›Full record

ArticleMicrobiology and immunology2026

Infection-Dependent Modulation of the Host Adaptor Gab2 During Chlamydia trachomatis Intracellular Development.

Sora Kuroiwa, Taiki Deguchi, Torahiko Okubo, Shinji Nakamura, Hideaki Higashi, Hiroyuki Yamaguchi

Abstract read
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In one paragraph

Article in Microbiology and immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sora KuroiwaDepartment of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Taiki DeguchiDepartment of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Torahiko OkuboDepartment of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Shinji NakamuraDivision of Biomedical Imaging Research, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
Hideaki HigashiDivision of Infection and Immunity, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Hiroyuki YamaguchiDepartment of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.ORCID https://orcid.org/0000-0003-3723-3361

Funding

Japan Society for the Promotion of Science 25K02490
6 · The paper itself

Abstract

Chlamydia trachomatis (Ct) is an obligate intracellular bacterium that can cause severe reproductive complications, including infertility and pelvic inflammatory disease. Its pathogenicity depends on intracellular maturation, which involves differentiation between infectious elementary (EB) and replicative reticulate bodies within inclusion vacuoles. Ct is known to modulate host PI3K-AKT signaling during this process; however, the molecular basis of this regulation remains unclear. To elucidate this mechanism, we screened host factors linked to the PI3K-AKT axis using a PI3K-AKT-mTOR compound library comprising 319 inhibitors, and identified the adaptor protein Gab2 (GRB2-associated binding protein 2) as a new target molecule of Ct. Gab2 protein levels decreased during the late phase of infection, and Gab2 silencing impaired intracellular replication without affecting EB formation. These findings demonstrate that Ct infection modulates the host adaptor Gab2 during intracellular development and provide new insights into host-pathogen interactions underlying chlamydial maturation.

Indexed as

Adaptor Proteins, Signal TransducingChlamydia InfectionsChlamydia trachomatisHost-Pathogen InteractionsHeLa CellsHumansPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionAdaptor Proteins, Signal TransducingGAB2 protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktcellular adaptationChlamydia trachomatisGab2inhibitor‐panel screeningPI3K‐AKT

Identifiers

PMID42387659
PMCPMC13551657

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.