Evidence map›Paper›PMID 42387657›Full record

ArticleClinical epigenetics2026

The role of epigenetic age acceleration and social disadvantage in cardiometabolic health in southeast Louisiana women.

Alicia K Smith, Seyma Katrinli, Julian L Moran, Kristyne D Mansilla Dubon, Sierra N Garth, Michael Simmond, Dawayland O Cobb, Meghan Brashear, Edward J Trapido, Erika J Wolf and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alicia K SmithDepartment of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, USA.
Seyma KatrinliDepartment of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, USA.
Julian L MoranSchool of Medicine, Emory University, Atlanta, USA.
Kristyne D Mansilla DubonEpidemiology Department, University of Nebraska Medical Center College of Public Health, Omaha, USA.
Sierra N GarthEpidemiology Department, University of Nebraska Medical Center College of Public Health, Omaha, USA.
Michael SimmondDepartment of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, USA.
Dawayland O CobbDepartment of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, USA.
Meghan BrashearEpidemiology Department, University of Nebraska Medical Center College of Public Health, Omaha, USA.
Edward J TrapidoEpidemiology Program, Louisiana State University School of Public Health, New Orleans, USA.
Erika J WolfDepartment of Psychiatry, National Center for PTSD at VA Boston Healthcare System, Boston University Chobanian & Avedisian School of Medicine, Boston, USA.
Ariane L RungEpidemiology Department, University of Nebraska Medical Center College of Public Health, Omaha, USA.
Nicole R Nugent *Department of Psychiatry and Human Behavior, Alpert Brown Medical School, Providence, USA. nicole_nugent@brown.edu.ORCID http://orcid.org/0000-0001-8756-5618
Edward S Peters *Epidemiology Department, University of Nebraska Medical Center College of Public Health, Omaha, USA.

Funding

The Women and [Their] Children's Gulf Health ConsortiumU01ES021497 · NIEHS · LSU HEALTH SCIENCES CENTER · PI TRAPIDO, EDWARD J. · 2011 to 2015
$4.0M
The Impact of Environmental Stressors on Chronic Disease Disparities in WomenR01AG069609 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI NUGENT, NICOLE R, PETERS, EDWARD S · 2021 to 2025
$3.0M
NIA NIH HHS R01 AG069609NIEHS NIH HHS U01 ES021497NIH HHS R01AG069609, 1U01ES021497
6 · The paper itself

Abstract

backgroundCardiometabolic risk factors can disrupt DNA methylation (DNAm) patterns, accelerate cellular aging, and contribute to age-related disorders, including cardiovascular disease (CVD) and diabetes. Social disadvantage may exacerbate these biological processes, yet its relationship with epigenetic aging and cardiometabolic disease across time remains incompletely understood. We examined associations between epigenetic age acceleration and both social disadvantage and cardiometabolic diseases. We assessed whether these associations differed in each study wave.

resultsParticipants were drawn from The Women and Their Children's Health (WaTCH) cohort and assessed at Wave 1 (2012-2014; N = 865) and Wave 3 (2023-2025; N = 348). At Wave 1, participants had a mean age of 46.9 ± 11.9 years and identified as Black (38.0%) or White (56.2%). Social disadvantage was assessed using an individual-level socioeconomic status (SES) index (education, income, and health insurance) and the Area Deprivation Index (ADI). DNAm was measured from blood samples to derive epigenetic age acceleration metrics (GrimAge2, PhenoAge, and DunedinPACE). Lower SES index and higher ADI were associated with greater epigenetic age acceleration and a faster pace of aging. CVD (45.2%) and diabetes (15.6%) at Wave 1 were more prevalent among participants with lower SES index, higher ADI, Black race, and higher body mass index (BMI). After adjustment for BMI, alcohol use, ADI, SES, smoking, and cell composition, both CVD and diabetes were associated with higher GrimAge2 and PhenoAge acceleration and a faster pace of aging at Wave 1. At Wave 3, diabetes was associated with all measures of epigenetic age acceleration after covariate adjustment.

conclusionsCVD and diabetes were more common among socially disadvantaged women and were associated with accelerated epigenetic aging. These findings highlight the biological correlates of social disadvantage and underscore the need for targeted public health interventions addressing social drivers of health to mitigate cardiometabolic disease risk.

Indexed as

AgingCardiovascular DiseasesEpigenesis, GeneticSocial VulnerabilityAdultCardiometabolic Risk FactorsDNA MethylationEpigenomicsFemaleHumansLouisianaMiddle AgedSocial ClassSocioeconomic Disparities in HealthArea Deprivation IndexCardiometabolic diseaseCardiovascular diseaseDiabetesDNA methylationEpigenetic age accelerationSocial disadvantageSocioeconomic statusWomen’s health

Identifiers

PMID42387657
PMCPMC13595649

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.