ArticleBMC research notes2026
Modulation of brain-kidney crosstalk by olanzapine in aluminum chloride-induced memory impairment: a preclinical investigation.
Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe study investigated the impact of OLN on cognitive function, oxidative stress, neuroinflammation, and renal functions in a mouse model of aluminum chloride (AlCl₃) induced memory impairment. Twenty-five male mice were divided into five groups: group 1 (control) distilled water (10 mL/kg), group II AlCl₃ (100 mg/kg), group III AlCl₃ + OLN (0.5 mg/kg), group IV AlCl₃ + OLN (1.0 mg/kg), and group V AlCl₃ + Donepezil (1 mg/kg). Treatments were administered orally for seven days. Cognitive performance was assessed via Y-maze and open field test. Post-sacrifice, brain and kidney tissues were harvested and analysed for the levels of malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), tumour necrosis factor-alpha (TNF-α), nitrites, urea, and total protein, alongside histological examination of the hippocampus and prefrontal cortex.
resultsAlCl₃ significantly impaired cognitive and locomotor performance, elevated MDA, TNF-α, nitrite, urea levels, and reduced GSH, CAT, SOD and total protein. Histological studies showed that AlCl
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