Evidence map›Paper›PMID 42387594›Full record

ArticleStem cell research & therapy2026

SATB1 regulates the osteogenic differentiation of PDLSCs via HDAC1 mediated non-histone protein deacetylation and ubiquitination mechanism and through p38 MAPK pathway under hydrogen peroxide-induced senescent conditions.

Meijun Hu, Jiaxin Song, Wanhao Yan, Yu Jiang, Chen Zhang, Haoqing Yang, Zhipeng Fan

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In one paragraph

Article in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Meijun HuLaboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Beijing Stomatological Hospital, Capital Medical University, No. 9 Fanjia village, Fengtai District, Beijing, 100070, China.
Jiaxin SongLaboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Beijing Stomatological Hospital, Capital Medical University, No. 9 Fanjia village, Fengtai District, Beijing, 100070, China.
Wanhao YanLaboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Beijing Stomatological Hospital, Capital Medical University, No. 9 Fanjia village, Fengtai District, Beijing, 100070, China.
Yu JiangBiomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Chen ZhangLaboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Beijing Stomatological Hospital, Capital Medical University, No. 9 Fanjia village, Fengtai District, Beijing, 100070, China.
Haoqing YangLaboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Beijing Stomatological Hospital, Capital Medical University, No. 9 Fanjia village, Fengtai District, Beijing, 100070, China.
Zhipeng FanLaboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Beijing Stomatological Hospital, Capital Medical University, No. 9 Fanjia village, Fengtai District, Beijing, 100070, China. zpfan@ccmu.edu.cn.

Funding

the National Key Research and Development Program 2025YFC2423201Young Scientist Program of Beijing Stomatological Hospital YSP202502
6 · The paper itself

Abstract

backgroundPeriodontitis is a chronic inflammatory disease that affects the supporting tissues around teeth. A reduction in the pluripotency of periodontal ligament stem cells (PDLSCs) has been identified as a pivotal factor in age-related alveolar bone loss. This study investigated the effects of special AT-rich binding protein 1 (SATB1) on the osteogenic differentiation capacity of PDLSCs under H

methodsThe osteogenic differentiation capacity of PDLSCs was determined by alkaline phosphatase (ALP) activity, alizarin red S (ARS) staining, and western blotting. Co-immunoprecipitation (Co-IP) was used to detect the binding of SATB1 to histone deacetylase 1 (HDAC1) and a ubiquitination assay was employed to detect the protein stability of SATB1.

resultsUnder normal and H

conclusionsSATB1 modulated the osteogenic differentiation of PDLSCs through HDAC1 mediated non-histone protein deacetylation and ubiquitination and through the p38 MAPK pathway under H

Indexed as

Cell DifferentiationHistone Deacetylase 1Hydrogen PeroxideMatrix Attachment Region Binding ProteinsOsteogenesisp38 Mitogen-Activated Protein KinasesPeriodontal LigamentStem CellsAcetylationCells, CulturedCellular SenescenceHumansMAP Kinase Signaling SystemUbiquitinationHDAC1 protein, humanHistone Deacetylase 1Hydrogen PeroxideMatrix Attachment Region Binding Proteinsp38 Mitogen-Activated Protein KinasesSATB1 protein, humanHDAC1MAPK pathwayPDLSCsSATB1SenescenceUbiquitination

Identifiers

PMID42387594
PMCPMC13595774

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.