Evidence map›Paper›PMID 42387559›Full record

ArticleJournal of cheminformatics2026

OpenStats: how to combine statistics and research data management (RDM) to leverage efficient scientific data analysis by guided statistics.

Konrad Krämer, Pierre Tremouilhac, Fabian Mauz, Christoph Grathwol, Nicole Jung, Stefan Bräse

Abstract read
In one paragraph

Article in Journal of cheminformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Konrad KrämerInstitute of Biological and Chemical Systems, Functional Molecular Systems (IBCS), Karlsruhe Institute of Technology, Kaiserstraße 12, 76131, Karlsruhe, Germany.
Pierre TremouilhacInstitute of Biological and Chemical Systems, Functional Molecular Systems (IBCS), Karlsruhe Institute of Technology, Kaiserstraße 12, 76131, Karlsruhe, Germany.
Fabian MauzDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry (IPB), Weinberg 3, 06120, Halle (Saale), Germany.
Christoph GrathwolInstitute of Biological and Chemical Systems, Functional Molecular Systems (IBCS), Karlsruhe Institute of Technology, Kaiserstraße 12, 76131, Karlsruhe, Germany.
Nicole JungInstitute of Biological and Chemical Systems, Functional Molecular Systems (IBCS), Karlsruhe Institute of Technology, Kaiserstraße 12, 76131, Karlsruhe, Germany. nicole.jung@kit.edu.
Stefan BräseInstitute of Biological and Chemical Systems, Functional Molecular Systems (IBCS), Karlsruhe Institute of Technology, Kaiserstraße 12, 76131, Karlsruhe, Germany. stefan.braese@kit.edu.

Funding

Deutsche Forschungsgemeinschaft 441958208Helmholtz-Gemeinschaft Research Field Information 43.33.11
6 · The paper itself

Abstract

We developed OpenStats, a user-friendly web application that brings the power of the R language to researchers through a high-level interface and broad support for statistical methods such as t-tests and ANOVA. OpenStats was integrated into our electronic lab notebook Chemotion ELN via its third-party API, enabling direct data exchange with it. A pivotal feature of OpenStats is its ability to record each analysis step in a structured history. This record allows users to retrace their work and enables automatic replay of the entire analysis, promoting reproducibility and long-term data integrity. In the modern research landscape, Research Data Management (RDM) tools like electronic lab notebooks (ELNs) are crucial for generating reproducible, repeatable, and transparently documented data. However, integrating statistical analysis tools into RDM systems remained a challenge. We demonstrated how OpenStats can be seamlessly linked to Research Data Management (RDM) systems, using Chemotion ELN as a reference implementation, by our application to a standard dose-response assay scenario. This linkage allows the integration of statistical data analysis in the form of a closed, traceable workflow into the RDM world. It therefore complements systems that are aiming for reproducible and standardized workflows in the scientific environment.

Identifiers

PMID42387559
PMCPMC13330261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.