Evidence map›Paper›PMID 42387540›Full record

ReviewJournal of nanobiotechnology2026

Platelet concentrates integrated with tissue engineering scaffolds: a promising approach for wound healing application.

Yinglin Xu, Chunlei Dai, Jianlin Huang, Yiqun Wu, Liying Wang, Jun Wu

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yinglin XuBioscience and Biomedical Engineering Thrust, The Hongkong University of Science and Technology (Guangzhou), Guangzhou, 511400, Guangdong, China.
Chunlei DaiDepartment of Hematologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, China.
Jianlin HuangBioscience and Biomedical Engineering Thrust, The Hongkong University of Science and Technology (Guangzhou), Guangzhou, 511400, Guangdong, China.
Yiqun WuDepartment of Pharmacy, Xuzhou Central Hospital, Southeast University, Xuzhou, 221009, Jiangsu, China. WuyiqunCPU@163.com.
Liying WangDepartment of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, Guangdong, China. wangly53@alumni.sysu.edu.cn.
Jun WuBioscience and Biomedical Engineering Thrust, The Hongkong University of Science and Technology (Guangzhou), Guangzhou, 511400, Guangdong, China. junwuhkust@hkust-gz.edu.cn.

Funding

National Key Research and Development Program of China 2025YFA0921400National Natural Science Foundation of China U22A20315
6 · The paper itself

Abstract

Wound healing is a complex process involving various factors and reconstruction of tissue structures. Platelets and their bioactive substances play an indispensable role in various stages of wound healing. Tissue engineering scaffolds are instrumental in maintaining, repairing, and enhancing tissue structure and function. Combining platelet concentrates with tissue engineering scaffolds heralds a novel direction for wound healing research. In this combination, platelet concentrates serve as tissue repair facilitators, while scaffolds function as tissue support and drug release platforms. This synergistic approach produces superior tissue repair outcomes in comparison to using either method independently. As a result, it is crucial to consolidate the application of platelet concentrates with tissue engineering scaffolds in the context of wound healing. This review begins by exploring the role of platelet concentrates and tissue engineering scaffolds in wound healing, while also outlining the essential criteria that scaffolds must meet. It then summarizes the application advances of platelet concentrates combined with tissue engineering scaffolds in wound healing. Finally, we highlighted current limitations in translation, including interpatient variability, formulation reproducibility, and complex regulatory hurdles. Developing innovative strategies and delving deeper into potential molecular mechanisms will drive further advancements in wound healing therapies through biomaterials engineering.

Indexed as

Blood PlateletsTissue EngineeringTissue ScaffoldsWound HealingAnimalsBiocompatible MaterialsHumansBiocompatible MaterialsAngiogenesisBiomaterialsChronic ulcersDrug delivery systemsPRPTissue regeneration

Identifiers

PMID42387540
PMCPMC13595549

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.