ArticleJournal of cardiothoracic surgery2026
Association of red cell distribution width and lymphocyte count with the presence and severity of calcific aortic valve stenosis.
Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCalcific aortic valve stenosis (CAVS) is the most common valvular heart disease in the elderly, with pathogenesis involving chronic inflammation and oxidative stress. Identifying reliable, low-cost biomarkers for disease presence and severity remains a clinical priority.
objectiveTo evaluate the prognostic significance of red cell distribution width (RDW) and lymphocyte count (LC) in assessing the presence and severity of CAVS.
methodsIn this retrospective study, 377 patients with echocardiographically confirmed CAVS and 309 healthy controls were analyzed. CAVS severity was stratified as mild, moderate, or severe. RDW and LC were measured from routine blood tests. Associations with CAVS severity were examined using correlation and logistic regression analyses. ROC curve analysis assessed the predictive performance of RDW and LC for severe CAVS.
resultsRDW levels increased progressively with CAVS severity (13.0%, 14.6%, and 15.5% for mild, moderate, and severe groups; p < 0.001), while LC decreased. RDW positively correlated with systolic transaortic gradient (r = 0.319, p < 0.001); LC was inversely correlated (r = -0.262, p < 0.001). Multivariate analysis identified RDW (OR: 2.519; 95% CI: 2.058-3.083; p < 0.001) and LC (OR: 0.261; 95% CI: 0.150-0.454; p < 0.001) as independent predictors of CAVS. RDW yielded an AUC of 0.774; LC had an AUC of 0.323.
conclusionElevated RDW and reduced LC are independently associated with the presence and severity of CAVS. These findings suggest that these hematological indices may reflect underlying systemic processes and could serve as adjunct markers in the clinical assessment of disease burden, although their prognostic utility requires further validation.
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