Evidence map›Paper›PMID 42387508›Full record

ArticleJournal of biomedical science2026

Calcium and phosphorylation coordination is a novel mechanism that stabilises protein-complexes during HIV assembly.

Erwan Brémaud, Biswa Prasanna Mishra, Ablikim Baqi, Veronika Masic, Thibaut Flipo, Arun Everest-Dass, Lauren Hartley-Tassell, Paul R Gorry, Thomas Ve, Belinda L Spillings and 1 more

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Article in Journal of biomedical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Erwan BrémaudInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, QLD, Australia.
Biswa Prasanna MishraInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, QLD, Australia.
Ablikim BaqiInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, QLD, Australia.
Veronika MasicInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, QLD, Australia.
Thibaut FlipoInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, QLD, Australia.
Arun Everest-DassInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, QLD, Australia.
Lauren Hartley-TassellInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, QLD, Australia.
Paul R GorryThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.
Thomas VeInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, QLD, Australia.
Belinda L SpillingsInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, QLD, Australia.
Johnson MakInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, QLD, Australia. j.mak@griffith.edu.au.ORCID https://orcid.org/0000-0002-5229-5707

Funding

Dichotomy of HIV-Sugar with Vaginal MicrobesR21AI172534 · NIAID · GRIFFITH UNIVERSITY · PI MAK, JOHNSON · 2023 to 2024
$297k
Australian Research Council FT100100297Australian Research Council FT200100572National Health and Medical Research Council 1121697National Health and Medical Research Council 1196590NIAID NIH HHS R21 AI172534NIH HHS NIAID R21AI172534
6 · The paper itself

Abstract

backgroundCalcium (Ca

methodsIn this work, we have utilised a combination of molecular virology, phosphorylation proteomics mass spectrometry, surface plasmon resonance, nuclear magnetic resonance, AlphaFold structural prediction, and electron microscopy imaging to systematically evaluated the biology of calcium - phosphorylation interplay.

resultsHere, we leveraged HIV-Ca

conclusionsOur work has identified the coordination between calcium and phosphorylated amino acids (presumably via the formation of a salt-bridge) is an unknown layer of regulation that support protein complex formation. In the context of HIV, these Ca

Indexed as

CalciumHIV-1Virus AssemblyHumansPhosphorylationCalciumBiophysicsCalciumCalcium-phosphate bridgeDisorderedEndosomal sorting complex required for transportESCRTExocytosisHIV assemblyIntrinsically disorder proteinsPESTPhosphorylation switchPr160GagPolPr55GagProtein complex stabilityRyanodine receptorsTSG101UbiquitinationVirological synapses

Identifiers

PMID42387508
PMCPMC13326380

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.