Observational studyBMC pulmonary medicine2026
Airway structural involvement detected by quantitative computed tomography in controlled and uncontrolled asthma.
Observational study in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundStructural airway changes (airway remodeling) are traditionally associated with severe and uncontrolled asthma. The extent to which they are present in asthmatics with different clinical control statuses is unknown. Quantitative computed tomography (qCT) is an underused tool for assessing airway morphology and remodeling. In this study, we aimed to compare airway morphology between individuals with severe uncontrolled asthma (SA), controlled asthma (CA), and non-asthmatic controls (C) using qCT. We also sought correlations between qCT metrics and spirometric measurements.
methodsIn this cross-sectional observational study, we recruited asthmatics (SA, CA) and non-asthmatic controls (C) aged 18-65 between March 2016 and February 2018. All subjects underwent spirometry and high-resolution chest computed tomography (CT). Quantitative CT analysis was performed using an automated software (YACTA v2.7). Airway metrics included total airway count (TAC), airway wall thickness (WT), relative wall thickness (Wall%), lumen area (LA) and mean maximal attenuation of airway walls. We compared groups using ANOVA and investigated correlations between spirometry and qCT metrics through Pearson coefficients.
resultsSeventy-six individuals were included (SA n = 27, CA n = 28, C n = 21). Severe uncontrolled asthmatics were taking more intense asthma treatment and had lower forced expiratory volume in the first second (FEV1) compared with CA and C groups (FEV1%predicted: 55.37 + 12.64 × 91.21 + 9.74 × 104.93 + 15.7, respectively; p = 0.0001). Wall% (49.4 + 3.38 × 48.3 + 4.51 × 45.3 + 3.71; p = 0.001) and WT were higher in both asthma groups compared with controls (2.06 + 0.28 × 1.89 + 0.34 × 1.62 + 0.27; p = 0.0001; mm; 3rd bronchial generation); TAC was progressively greater from SA to CA and C groups (27.22 + 17.29 × 43,61 + 20,11 × 57,23 + 16,82; p = 0.0001). Lumen area (bronchial 3rd generation, in mm2) was lower in SA than in CA and C (52.95 + 17.29 × 65.78 + 14.53 × 66.92 + 13.57; p = 0.002). Forced expiratory volume in the first second correlated positively with TAC (r = 0.67) and negatively with Wall% (r=-0.59).
conclusionsOur findings defy the usual outlook of morphological airway involvement only in severe asthma. Further studies are needed to explore the nature of structural involvement in CA, while we showed the usefulness of qCT in evaluating seldom-assessed elements of asthma pathophysiology.
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