Evidence map›Paper›PMID 42387448›Full record

ArticleBMC public health2026

Cross-border food reformulation: changes in nutrient content in Uruguay following the implementation of front-of-package policies in neighbouring countries.

Gastón Ares, Florencia Alcaire, Gimena Allegue, Lucía Antúnez, Evelyn Gitz, Sofía Rincon Gallardo, Virginia Natero

Abstract read
In one paragraph

Article in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Gastón AresInstituto Polo Tecnológico de Pando, Facultad de Química, Universidad de la República, By Pass de Rutas 8 y 101 S/N, Pando, Canelones, CP 91000, Uruguay. gares@fq.edu.uy.ORCID http://orcid.org/0000-0002-0565-8835
Florencia AlcaireInstituto Polo Tecnológico de Pando, Facultad de Química, Universidad de la República, By Pass de Rutas 8 y 101 S/N, Pando, Canelones, CP 91000, Uruguay.
Gimena AllegueInterdisciplinary Center on Food and Wellbeing, Espacio Interdisciplinario, Universidad de la República, José Enrique Rodó 1843, Montevideo, CP 11200, Uruguay.
Lucía AntúnezInstituto Polo Tecnológico de Pando, Facultad de Química, Universidad de la República, By Pass de Rutas 8 y 101 S/N, Pando, Canelones, CP 91000, Uruguay.
Evelyn GitzGlobal Health Advocacy Incubator, 1400 I St NW #1200, Washington, DC, 20005, USA.
Sofía Rincon GallardoGlobal Health Advocacy Incubator, 1400 I St NW #1200, Washington, DC, 20005, USA.ORCID http://orcid.org/0000-0002-7997-1971
Virginia NateroInterdisciplinary Center on Food and Wellbeing, Espacio Interdisciplinario, Universidad de la República, José Enrique Rodó 1843, Montevideo, CP 11200, Uruguay.

Funding

Espacio Interdisciplinario, Universidad de la República N/AGlobal Health Advocacy Incubator N/A
6 · The paper itself

Abstract

backgroundFood reformulation is frequently discussed as a potential strategy to address obesity and diet-related non-communicable diseases. However, evidence regarding its effectiveness and broader implications within globalised food systems remains limited. This study examined changes in the nutrient content of packaged foods commercialised in Uruguay between 2021 and 2025, a period characterised by limited domestic regulatory action but during which front-of-package (FOP) warning label policies were implemented in Argentina and Brazil, Uruguay's main trading partners.

methodsNutrient information was obtained through systematic in-store data collection and compiled into an online database. Linear mixed-effects models were used to estimate changes in nutrient content, accounting for repeated product-level observations and testing interactions between year and country of origin.

resultsAt the aggregate level, modest but statistically significant reductions were observed in total fat, saturated fat, and sodium, alongside a small increase in fibre content. However, significant interactions between year and country of origin revealed substantial heterogeneity in reformulation patterns. Products imported from Argentina showed the most pronounced reformulation, with significant reductions in total fat, saturated fat, and sodium, and increases in fibre content. In contrast, domestically produced products in Uruguay exhibited limited reformulation, with statistically significant changes observed only for saturated fat and of smaller magnitude. Products from Brazil and other countries showed minimal changes, with statistically significant increases limited to fibre content. Category-level analyses further indicated that reformulation effects were uneven across the packaged food supply.

conclusionsThese findings are consistent with the possibility that the implementation of FOP warning labels in Argentina was associated with reformulation with spillover effects into the Uruguayan market. Differences in policy design, particularly the stringency of the underlying nutrient profile model, may help explain the divergent industry responses. The limited changes observed among domestic products in the period highlight the need for complementary policy instruments to promote more substantial reformulation.

Indexed as

Food LabelingFood PackagingNutrition PolicyNutritive ValueArgentinaBrazilHumansUruguayFood policyFood reformulationFront-of-packageNutrition labellingTrans-fat

Identifiers

PMID42387448
PMCPMC13591798

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.