ArticleBMC pregnancy and childbirth2026
Diagnostic performance of serum uric acid and proteinuria for classifying pre-eclampsia severity among pregnant women at Banadir Hospital, Mogadishu, Somalia: a comparative cross-sectional study.
Article in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPre-eclampsia is a major cause of maternal and perinatal morbidity and mortality, particularly in low-resource settings. While hypertension and proteinuria are central to diagnosis, additional biomarkers may assist in classifying disease severity at presentation. Serum uric acid (SUA) has been linked to endothelial dysfunction and oxidative stress in pre-eclampsia, but evidence from Somalia is limited.
objectiveTo assess the diagnostic performance of serum uric acid in classifying pre-eclampsia severity and to compare its discriminatory ability with semi-quantitative proteinuria among pregnant women attending Banadir Hospital, Mogadishu, Somalia.
methodsA hospital-based comparative cross-sectional study was conducted among 322 pregnant women (161 normotensive controls and 161 women with pre-eclampsia) at Banadir Hospital. Pre-eclampsia cases were classified into non-severe and severe disease based on standard clinical criteria. Serum uric acid levels and urine protein were measured at presentation. Receiver operating characteristic (ROC) curve analysis was used to evaluate the ability of serum uric acid and proteinuria to discriminate severe from non-severe pre-eclampsia, and areas under the curve (AUCs) were compared using the DeLong test.
resultsSerum uric acid levels increased progressively from normotensive pregnancy to non-severe and severe pre-eclampsia (p < 0.001). Women with severe pre-eclampsia had significantly higher serum uric acid and proteinuria levels compared with those without severe features. Serum uric acid demonstrated excellent discriminatory performance for classifying disease severity (AUC = 0.985; 95% CI: 0.972-0.998). Internal validation using bootstrap resampling (5,000 iterations) confirmed stable performance (bootstrap AUC = 0.985; 95% CI: 0.970-0.997). The optimal cut-off value for serum uric acid was 7.0 mg/dL, which yielded a sensitivity of 95.1% and a specificity of 96.3%. Proteinuria showed comparable performance (AUC = 0.986; 95% CI: 0.978-0.995; bootstrap AUC = 0.986; 95% CI: 0.977-0.994), with no statistically significant difference between the two biomarkers (p > 0.05).
conclusionSerum uric acid was significantly associated with pre-eclampsia severity and demonstrated excellent ability to discriminate severe from non-severe disease at presentation, comparable to semi-quantitative proteinuria. Serum uric acid may serve as a useful complementary laboratory marker for severity classification in tertiary referral settings, particularly in low-resource environments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.